Practical synthesis of Schollkopf's bis-lactim ether chiral auxiliary: (3S)-3,6-dihydro-2,5-dimethoxy-3-isopropyl-pyrazine
Practical methodology for the bis-O-methylation of (3S)-isopropyl-piperazine-2,5-dione 4 on a 45 g scale to generate Schollkopf's bis-lactim ether chiral auxiliary (3S)-3,6-dihydro-2,5-dimethoxy-3-isopropyl-pyrazine 1 has been developed. Monomethylated intermediates 5 and 6 are reported for the...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1998
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| _version_ | 1797063046330318848 |
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| author | Bull, S Davies, S Moss, W |
| author_facet | Bull, S Davies, S Moss, W |
| author_sort | Bull, S |
| collection | OXFORD |
| description | Practical methodology for the bis-O-methylation of (3S)-isopropyl-piperazine-2,5-dione 4 on a 45 g scale to generate Schollkopf's bis-lactim ether chiral auxiliary (3S)-3,6-dihydro-2,5-dimethoxy-3-isopropyl-pyrazine 1 has been developed. Monomethylated intermediates 5 and 6 are reported for the first time. The gelling effects of 4 in a range of common solvents are also described. |
| first_indexed | 2024-03-06T20:54:15Z |
| format | Journal article |
| id | oxford-uuid:38a1c3a6-ba5f-4486-855d-c98a08b4aa12 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:54:15Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:38a1c3a6-ba5f-4486-855d-c98a08b4aa122022-03-26T13:51:18ZPractical synthesis of Schollkopf's bis-lactim ether chiral auxiliary: (3S)-3,6-dihydro-2,5-dimethoxy-3-isopropyl-pyrazineJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:38a1c3a6-ba5f-4486-855d-c98a08b4aa12EnglishSymplectic Elements at Oxford1998Bull, SDavies, SMoss, WPractical methodology for the bis-O-methylation of (3S)-isopropyl-piperazine-2,5-dione 4 on a 45 g scale to generate Schollkopf's bis-lactim ether chiral auxiliary (3S)-3,6-dihydro-2,5-dimethoxy-3-isopropyl-pyrazine 1 has been developed. Monomethylated intermediates 5 and 6 are reported for the first time. The gelling effects of 4 in a range of common solvents are also described. |
| spellingShingle | Bull, S Davies, S Moss, W Practical synthesis of Schollkopf's bis-lactim ether chiral auxiliary: (3S)-3,6-dihydro-2,5-dimethoxy-3-isopropyl-pyrazine |
| title | Practical synthesis of Schollkopf's bis-lactim ether chiral auxiliary: (3S)-3,6-dihydro-2,5-dimethoxy-3-isopropyl-pyrazine |
| title_full | Practical synthesis of Schollkopf's bis-lactim ether chiral auxiliary: (3S)-3,6-dihydro-2,5-dimethoxy-3-isopropyl-pyrazine |
| title_fullStr | Practical synthesis of Schollkopf's bis-lactim ether chiral auxiliary: (3S)-3,6-dihydro-2,5-dimethoxy-3-isopropyl-pyrazine |
| title_full_unstemmed | Practical synthesis of Schollkopf's bis-lactim ether chiral auxiliary: (3S)-3,6-dihydro-2,5-dimethoxy-3-isopropyl-pyrazine |
| title_short | Practical synthesis of Schollkopf's bis-lactim ether chiral auxiliary: (3S)-3,6-dihydro-2,5-dimethoxy-3-isopropyl-pyrazine |
| title_sort | practical synthesis of schollkopf s bis lactim ether chiral auxiliary 3s 3 6 dihydro 2 5 dimethoxy 3 isopropyl pyrazine |
| work_keys_str_mv | AT bulls practicalsynthesisofschollkopfsbislactimetherchiralauxiliary3s36dihydro25dimethoxy3isopropylpyrazine AT daviess practicalsynthesisofschollkopfsbislactimetherchiralauxiliary3s36dihydro25dimethoxy3isopropylpyrazine AT mossw practicalsynthesisofschollkopfsbislactimetherchiralauxiliary3s36dihydro25dimethoxy3isopropylpyrazine |