Catalysis by the non-heme iron(II) histone demethylase PHF8 involves iron center rearrangement and conformational modulation of substrate orientation

Catalysis by the non-heme iron(II) histone demethylase PHF8 involves iron center rearrangement and conformational modulation of substrate orientation

PHF8 (KDM7B) is a human non-heme 2-oxoglutarate (2OG) JmjC domain oxygenase that catalyzes the demethylation of the di/mono-Nε-methylated K9 residue of histone H3. Altered PHF8 activity is linked to genetic diseases and cancer; thus, it is an interesting target for epigenetic modulation. We describe...

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Bibliografische gegevens
Hoofdauteurs:	Chaturvedi, SS, Ramanan, R, Lehnert, N, Schofield, CJ, Karabencheva-Christova, TG, Christov, CZ
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	American Chemical Society 2019

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