LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model.

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model.

Leucine rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD) although LRRK2 function remains unclear. We report a new role for LRRK2 in regulating autophagy and describe the recruitment of LRRK2 to the endosomal-autophagic pathway and specific mem...

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Bibliographic Details
Main Authors:	Alegre-Abarrategui, J, Christian, H, Lufino, M, Mutihac, R, Venda, L, Ansorge, O, Wade-Martins, R
Format:	Journal article
Language:	English
Published:	2009

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