The human Major Histocompatibility Complex as a paradigm in genomics research.
Since its discovery more than 50 years ago, the human Major Histocompatibility Complex (MHC) on chromosome 6p21.3 has been at the forefront of human genetic research. Here, we review from a historical perspective the major advances in our understanding of the nature and consequences of genetic varia...
| Autori principali: | , |
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| Natura: | Journal article |
| Lingua: | English |
| Pubblicazione: |
2009
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| _version_ | 1826267479171661824 |
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| author | Vandiedonck, C Knight, J |
| author_facet | Vandiedonck, C Knight, J |
| author_sort | Vandiedonck, C |
| collection | OXFORD |
| description | Since its discovery more than 50 years ago, the human Major Histocompatibility Complex (MHC) on chromosome 6p21.3 has been at the forefront of human genetic research. Here, we review from a historical perspective the major advances in our understanding of the nature and consequences of genetic variation which have involved the MHC, as well as highlighting likely future directions. As a consequence of its particular genomic structure, its remarkable polymorphism and its early implication in numerous diseases, the MHC has been considered as a model region for genomics, being the first substantial region to be sequenced and establishing fundamental concepts of linkage disequilibrium, haplotypic structure and meiotic recombination. Recently, the MHC became the first genomic region to be entirely re-sequenced for common haplotypes, while studies mapping gene expression phenotypes across the genome have strongly implicated variation in the MHC. This review shows how the MHC continues to provide new insights and remains in the vanguard of contemporary research in human genomics. |
| first_indexed | 2024-03-06T20:54:49Z |
| format | Journal article |
| id | oxford-uuid:38d4165b-4a8e-41cf-aefd-af30d96be915 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:54:49Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:38d4165b-4a8e-41cf-aefd-af30d96be9152022-03-26T13:52:18ZThe human Major Histocompatibility Complex as a paradigm in genomics research.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:38d4165b-4a8e-41cf-aefd-af30d96be915EnglishSymplectic Elements at Oxford2009Vandiedonck, CKnight, JSince its discovery more than 50 years ago, the human Major Histocompatibility Complex (MHC) on chromosome 6p21.3 has been at the forefront of human genetic research. Here, we review from a historical perspective the major advances in our understanding of the nature and consequences of genetic variation which have involved the MHC, as well as highlighting likely future directions. As a consequence of its particular genomic structure, its remarkable polymorphism and its early implication in numerous diseases, the MHC has been considered as a model region for genomics, being the first substantial region to be sequenced and establishing fundamental concepts of linkage disequilibrium, haplotypic structure and meiotic recombination. Recently, the MHC became the first genomic region to be entirely re-sequenced for common haplotypes, while studies mapping gene expression phenotypes across the genome have strongly implicated variation in the MHC. This review shows how the MHC continues to provide new insights and remains in the vanguard of contemporary research in human genomics. |
| spellingShingle | Vandiedonck, C Knight, J The human Major Histocompatibility Complex as a paradigm in genomics research. |
| title | The human Major Histocompatibility Complex as a paradigm in genomics research. |
| title_full | The human Major Histocompatibility Complex as a paradigm in genomics research. |
| title_fullStr | The human Major Histocompatibility Complex as a paradigm in genomics research. |
| title_full_unstemmed | The human Major Histocompatibility Complex as a paradigm in genomics research. |
| title_short | The human Major Histocompatibility Complex as a paradigm in genomics research. |
| title_sort | human major histocompatibility complex as a paradigm in genomics research |
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