Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.
We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significa...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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| _version_ | 1797063091907723264 |
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| author | Meyre, D Delplanque, J Chèvre, J Lecoeur, C Lobbens, S Gallina, S Durand, E Vatin, V Degraeve, F Proença, C Gaget, S Körner, A Kovacs, P Kiess, W Tichet, J Marre, M Hartikainen, A Horber, F Potoczna, N Hercberg, S Levy-Marchal, C Pattou, F Heude, B Tauber, M McCarthy, M |
| author_facet | Meyre, D Delplanque, J Chèvre, J Lecoeur, C Lobbens, S Gallina, S Durand, E Vatin, V Degraeve, F Proença, C Gaget, S Körner, A Kovacs, P Kiess, W Tichet, J Marre, M Hartikainen, A Horber, F Potoczna, N Hercberg, S Levy-Marchal, C Pattou, F Heude, B Tauber, M McCarthy, M |
| author_sort | Meyre, D |
| collection | OXFORD |
| description | We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P = 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7)). |
| first_indexed | 2024-03-06T20:54:56Z |
| format | Journal article |
| id | oxford-uuid:38d9b395-c05d-4879-9f54-da96165bca4b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:54:56Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:38d9b395-c05d-4879-9f54-da96165bca4b2022-03-26T13:52:39ZGenome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:38d9b395-c05d-4879-9f54-da96165bca4bEnglishSymplectic Elements at Oxford2009Meyre, DDelplanque, JChèvre, JLecoeur, CLobbens, SGallina, SDurand, EVatin, VDegraeve, FProença, CGaget, SKörner, AKovacs, PKiess, WTichet, JMarre, MHartikainen, AHorber, FPotoczna, NHercberg, SLevy-Marchal, CPattou, FHeude, BTauber, MMcCarthy, MWe analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P = 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7)). |
| spellingShingle | Meyre, D Delplanque, J Chèvre, J Lecoeur, C Lobbens, S Gallina, S Durand, E Vatin, V Degraeve, F Proença, C Gaget, S Körner, A Kovacs, P Kiess, W Tichet, J Marre, M Hartikainen, A Horber, F Potoczna, N Hercberg, S Levy-Marchal, C Pattou, F Heude, B Tauber, M McCarthy, M Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. |
| title | Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. |
| title_full | Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. |
| title_fullStr | Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. |
| title_full_unstemmed | Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. |
| title_short | Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. |
| title_sort | genome wide association study for early onset and morbid adult obesity identifies three new risk loci in european populations |
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