Ca(2+) signaling occurs via second messenger release from intraorganelle synthesis sites.

Ca(2+) signaling occurs via second messenger release from intraorganelle synthesis sites.

Cyclic ADP-ribose is an important Ca(2+)-mobilizing cytosolic messenger synthesized from beta-NAD(+) by ADP-ribosyl cyclases (ARCs). However, the focus upon ectocellular mammalian ARCs (CD38 and CD157) has led to confusion as to how extracellular enzymes generate intracellular messengers in response...

Full description

Bibliographic Details
Main Authors:	Davis, L, Morgan, A, Ruas, M, Wong, J, Graeff, R, Poustka, A, Lee, H, Wessel, G, Parrington, J, Galione, A
Format:	Journal article
Language:	English
Published:	2008

Similar Items

NAADP as an intracellular messenger regulating lysosomal calcium-release channels.
by: Galione, A, et al.
Published: (2010)

Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organelles.
by: Morgan, A, et al.
Published: (2013)

The luminal Ca2+ chelator, TPEN, inhibits NAADP-induced Ca2+ release
by: Morgan, A, et al.
Published: (2012)

The luminal Ca(2+) chelator, TPEN, inhibits NAADP-induced Ca(2+) release.
by: Morgan, A, et al.
Published: (2012)

NAADP: a new second messenger for glucose-induced Ca2+ responses in clonal pancreatic beta cells.
by: Masgrau, R, et al.
Published: (2003)

Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengers.
by: Cancela, J, et al.
Published: (2002)

Solubilization of receptors for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate.
by: Berridge, G, et al.
Published: (2002)

Two neuropeptides recruit different messenger pathways to evoke Ca2+ signals in the same cell.
by: Burdakov, D, et al.
Published: (2000)

Carvedilol inhibits cADPR- and IP3-induced Ca2+ release
by: Morgan, A, et al.
Published: (2017)

NAADP and cADPR signalling in sea urchin eggs
by: Galione, A, et al.
Published: (2005)

Synthesis of the Ca2+-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling
by: Lin, W, et al.
Published: (2017)

Physiological roles of NAADP-mediated Ca2+ signaling.
by: Galione, A, et al.
Published: (2011)

Interactions between calcium release pathways: multiple messengers and multiple stores.
by: Galione, A, et al.
Published: (2002)

Chemical synthesis of the novel Ca2+ messenger NAADP.
by: Dowden, J, et al.
Published: (2005)

Widespread distribution of binding sites for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate, in the brain.
by: Patel, S, et al.
Published: (2000)

NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores.
by: Galione, A
Published: (2006)

Sperm deliver a new second messenger: NAADP.
by: Churchill, G, et al.
Published: (2003)

Rapid, selective and dose-dependent elevation of the second messenger NAADP
by: Yamasaki, M, et al.
Published: (2005)

Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking.
by: Ruas, M, et al.
Published: (2010)

Two-pore channels for integrative Ca signaling.
by: Zhu, M, et al.
Published: (2010)

Extracellular calcium and cAMP: second messengers as "third messengers"?
by: Hofer, A, et al.
Published: (2007)

Two-pore channels for integrative Ca2+ signaling
by: Zhu, M, et al.
Published: (2010)

Identification and localisation of novel ADP-ribosyl cyclases in sea urchin eggs
by: Davis, L, et al.
Published: (2006)

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+.
by: Pitt, S, et al.
Published: (2010)

Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.
by: Ruas Da Silva, I, et al.
Published: (2015)

Convergent synthesis and unexpected Ca(2+)-mobilizing activity of 8-substituted analogues of cyclic ADP-carbocyclic-ribose, a stable mimic of the Ca(2+)-mobilizing second messenger cyclic ADP-ribose.
by: Shuto, S, et al.
Published: (2003)

cAMP: From long-range second messenger to nanodomain signalling
by: Musheshe, N, et al.
Published: (2017)

Metabolism of the novel Ca2+-mobilizing messenger nicotinic acid-adenine dinucleotide phosphate via a 2'-specific Ca2+-dependent phosphatase.
by: Berridge, G, et al.
Published: (2002)

Flipping the switch: how a sperm activates the egg at fertilization.
by: Parrington, J, et al.
Published: (2007)

An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell.
by: Arredouani, A, et al.
Published: (2010)

The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
by: Galione, A, et al.
Published: (2009)

Cyclic ADP ribose as a calcium-mobilizing messenger.
by: Galione, A, et al.
Published: (2000)

Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid “L-cyclic inosine 5′-diphosphate ribose”
by: Watt, J, et al.
Published: (2017)

Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease.
by: Morgan, A, et al.
Published: (2011)

Coordination of Ca2+ signalling by NAADP.
by: Patel, S, et al.
Published: (2001)

Heterogeneity of second messenger levels in living cells.
by: Zaccolo, M, et al.
Published: (2001)

NAADP: a novel Ca2+ mobilizing messenger during beta-adrenoceptor stimulation in guinea-pig ventricular myocytes
by: Yamasaki, M, et al.
Published: (2007)

Acidic Ca2+ stores and immune-cell function
by: Davis, LC, et al.
Published: (2021)

Membranes as messengers in T cell adhesion signaling.
by: Dustin, M, et al.
Published: (2004)

Ca(2+) release via two-pore channel type 2 (TPC2) is required for slow muscle cell myofibrillogenesis and myotomal patterning in intact zebrafish embryos
by: Kelu, JJ, et al.
Published: (2017)