Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset
<p>The recruitment and evolutionary optimization of promiscuous enzymes is key to the rapid adaptation of organisms to changing environments. Our understanding of the precise mechanisms underlying enzyme repurposing is, however, limited: What are the active-site features that enable the molecu...
| Main Authors: | , , , , , , , , , , |
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| 格式: | Journal article |
| 語言: | English |
| 出版: |
National Academy of Sciences
2018
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