Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate.

Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate.

Pyruvate dehydrogenase (PDH) is a key regulator of cardiac substrate selection and is regulated by both pyruvate dehydrogenase kinase (PDK)-mediated phosphorylation and feedback inhibition. The extent to which chronic upregulation of PDK protein levels, acutely increased PDK activity and acute feedb...

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Dettagli Bibliografici
Autori principali:	Schroeder, M, Atherton, H, Heather, L, Griffin, J, Clarke, K, Radda, G, Tyler, D
Natura:	Journal article
Lingua:	English
Pubblicazione:	2011

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