Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate.

Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate.

Pyruvate dehydrogenase (PDH) is a key regulator of cardiac substrate selection and is regulated by both pyruvate dehydrogenase kinase (PDK)-mediated phosphorylation and feedback inhibition. The extent to which chronic upregulation of PDK protein levels, acutely increased PDK activity and acute feedb...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Schroeder, M, Atherton, H, Heather, L, Griffin, J, Clarke, K, Radda, G, Tyler, D
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	2011

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