Left rostrolateral prefrontal cortex lesions reduce suicidal ideation in penetrating traumatic brain injury
<p><strong>Objectives.</strong> The objective of this study is to evaluate the relationship between suicidal ideation (SI), structural brain damage, and cognitive deficits in patients with penetrating traumatic brain injury (pTBI).</p> <p><strong>Methods.</str...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Cambridge University Press
2019
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| Summary: | <p><strong>Objectives.</strong>
The objective of this study is to evaluate the relationship between suicidal ideation (SI), structural brain damage, and cognitive deficits in patients with penetrating traumatic brain injury (pTBI).</p>
<p><strong>Methods.</strong>
Vietnam War veterans (n = 142) with pTBI to the prefrontal cortex (PFC) underwent combination of neuropsychological and psychiatric examinations and non-contrast CT brain scan. Patients were divided into SI positive (SI+) and SI negative (SI−) groups according to the SI item of the Beck Depression Inventory.</p>
<p><strong>Results.</strong>
Lesions to the left rostrolateral PFC (rlPFC) were associated with a lower risk of SI independent of depression and global functioning. Left rlPFC lesion also reduced abstract reasoning skills, which mediated the lesion effects on suicide ideation.</p>
<p><strong>Conclusions.</strong>
The left rlPFC plays a crucial role in SI independently of depression and global functioning.</p> |
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