Indices of nitric oxide synthesis and outcome in critically ill patients.

We measured the concentrations of serum nitrates/nitrites and plasma cyclic guanosine monophosphate as markers of nitric oxide synthesis in patients with or without septic shock for 5 days following admission to intensive care. We found that nitrate/nitrite concentrations, when corrected for the eff...

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Main Authors: MacKenzie, I, Garrard, C, Young, J
Format: Journal article
Language:English
Published: 2001
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author MacKenzie, I
Garrard, C
Young, J
author_facet MacKenzie, I
Garrard, C
Young, J
author_sort MacKenzie, I
collection OXFORD
description We measured the concentrations of serum nitrates/nitrites and plasma cyclic guanosine monophosphate as markers of nitric oxide synthesis in patients with or without septic shock for 5 days following admission to intensive care. We found that nitrate/nitrite concentrations, when corrected for the effect of renal failure, were significantly higher in patients with septic shock, both on admission and in the final samples drawn. In a logistic regression analysis, the rate of change of nitrate/nitrite concentration was associated with survival to day 28 (falling in survivors). The concentration of cyclic guanosine monophosphate when corrected for the confounding effects of renal function and platelet count, was only associated with the septic shock group on admission.
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spelling oxford-uuid:39605c9e-84cc-4902-8112-8e7709dc43142022-03-26T13:55:06ZIndices of nitric oxide synthesis and outcome in critically ill patients.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:39605c9e-84cc-4902-8112-8e7709dc4314EnglishSymplectic Elements at Oxford2001MacKenzie, IGarrard, CYoung, JWe measured the concentrations of serum nitrates/nitrites and plasma cyclic guanosine monophosphate as markers of nitric oxide synthesis in patients with or without septic shock for 5 days following admission to intensive care. We found that nitrate/nitrite concentrations, when corrected for the effect of renal failure, were significantly higher in patients with septic shock, both on admission and in the final samples drawn. In a logistic regression analysis, the rate of change of nitrate/nitrite concentration was associated with survival to day 28 (falling in survivors). The concentration of cyclic guanosine monophosphate when corrected for the confounding effects of renal function and platelet count, was only associated with the septic shock group on admission.
spellingShingle MacKenzie, I
Garrard, C
Young, J
Indices of nitric oxide synthesis and outcome in critically ill patients.
title Indices of nitric oxide synthesis and outcome in critically ill patients.
title_full Indices of nitric oxide synthesis and outcome in critically ill patients.
title_fullStr Indices of nitric oxide synthesis and outcome in critically ill patients.
title_full_unstemmed Indices of nitric oxide synthesis and outcome in critically ill patients.
title_short Indices of nitric oxide synthesis and outcome in critically ill patients.
title_sort indices of nitric oxide synthesis and outcome in critically ill patients
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AT garrardc indicesofnitricoxidesynthesisandoutcomeincriticallyillpatients
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