The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European prospective investigation into cancer and nutrition
Circulating concentrations of insulin-like growth factor I (IGF-I) and IGF binding proteins (IGFBP) have been associated with the risk of several types of cancer. Dietary correlates of IGF-I and IGFBPs are not yet well established. The objective of this study was to assess the association between di...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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| _version_ | 1797063200359841792 |
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| author | Crowe, F Key, T Allen, N Appleby, P Roddam, A Overvad, K Grønbæk, H Tjønneland, A Halkjær, J Dossus, L Boeing, H Kröger, J Trichopoulou, A Dilis, V Trichopoulos, D Boutron-Ruault, M De Lauzon, B Clavel-Chapelon, F Palli, D Berrino, F Panico, S Tumino, R Sacerdote, C Bueno-de-Mesquita, H Vrieling, A |
| author_facet | Crowe, F Key, T Allen, N Appleby, P Roddam, A Overvad, K Grønbæk, H Tjønneland, A Halkjær, J Dossus, L Boeing, H Kröger, J Trichopoulou, A Dilis, V Trichopoulos, D Boutron-Ruault, M De Lauzon, B Clavel-Chapelon, F Palli, D Berrino, F Panico, S Tumino, R Sacerdote, C Bueno-de-Mesquita, H Vrieling, A |
| author_sort | Crowe, F |
| collection | OXFORD |
| description | Circulating concentrations of insulin-like growth factor I (IGF-I) and IGF binding proteins (IGFBP) have been associated with the risk of several types of cancer. Dietary correlates of IGF-I and IGFBPs are not yet well established. The objective of this study was to assess the association between dietary intake and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in a cross-sectional analysis of 4,731 men and women taking part in the European Prospective Investigation into Cancer and Nutrition. Diet was assessed using country-specific validated dietary questionnaires. Serum concentrations of IGF-I, IGFBP-1, IGFBP-2 and IGFBP-3 were measured, and the associations between diet and IGF-I and IGFBPs were assessed using multiple linear regression adjusting for sex, age, body mass index, smoking status, and alcohol and energy intake. Each 1 SD increment increase in total and dairy protein and calcium intake was associated with an increase in IGF-I concentration of 2.5%, 2.4%, and 3.3%, respectively (P for trend <0.001 for all) and a decrease in IGFBP-2 of 3.5%, 3.5%, and 5.4% (P for trend <0.001 for all), respectively. There were no significant associations between the intake of protein or calcium from nondairy sources and IGF-I. The results from this large cross-sectional analysis show that either the intake of dairy protein or calcium is an important dietary determinant of IGF-I and IGFBP-2 concentrations; however, we suggest that it is more likely to be protein from dairy products. Copyright © 2009 American Association for Cancer Research. |
| first_indexed | 2024-03-06T20:56:24Z |
| format | Journal article |
| id | oxford-uuid:396d20a7-828f-42ea-bed9-39476b8c2bab |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:56:24Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:396d20a7-828f-42ea-bed9-39476b8c2bab2022-03-26T13:55:23ZThe association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European prospective investigation into cancer and nutritionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:396d20a7-828f-42ea-bed9-39476b8c2babEnglishSymplectic Elements at Oxford2009Crowe, FKey, TAllen, NAppleby, PRoddam, AOvervad, KGrønbæk, HTjønneland, AHalkjær, JDossus, LBoeing, HKröger, JTrichopoulou, ADilis, VTrichopoulos, DBoutron-Ruault, MDe Lauzon, BClavel-Chapelon, FPalli, DBerrino, FPanico, STumino, RSacerdote, CBueno-de-Mesquita, HVrieling, ACirculating concentrations of insulin-like growth factor I (IGF-I) and IGF binding proteins (IGFBP) have been associated with the risk of several types of cancer. Dietary correlates of IGF-I and IGFBPs are not yet well established. The objective of this study was to assess the association between dietary intake and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in a cross-sectional analysis of 4,731 men and women taking part in the European Prospective Investigation into Cancer and Nutrition. Diet was assessed using country-specific validated dietary questionnaires. Serum concentrations of IGF-I, IGFBP-1, IGFBP-2 and IGFBP-3 were measured, and the associations between diet and IGF-I and IGFBPs were assessed using multiple linear regression adjusting for sex, age, body mass index, smoking status, and alcohol and energy intake. Each 1 SD increment increase in total and dairy protein and calcium intake was associated with an increase in IGF-I concentration of 2.5%, 2.4%, and 3.3%, respectively (P for trend <0.001 for all) and a decrease in IGFBP-2 of 3.5%, 3.5%, and 5.4% (P for trend <0.001 for all), respectively. There were no significant associations between the intake of protein or calcium from nondairy sources and IGF-I. The results from this large cross-sectional analysis show that either the intake of dairy protein or calcium is an important dietary determinant of IGF-I and IGFBP-2 concentrations; however, we suggest that it is more likely to be protein from dairy products. Copyright © 2009 American Association for Cancer Research. |
| spellingShingle | Crowe, F Key, T Allen, N Appleby, P Roddam, A Overvad, K Grønbæk, H Tjønneland, A Halkjær, J Dossus, L Boeing, H Kröger, J Trichopoulou, A Dilis, V Trichopoulos, D Boutron-Ruault, M De Lauzon, B Clavel-Chapelon, F Palli, D Berrino, F Panico, S Tumino, R Sacerdote, C Bueno-de-Mesquita, H Vrieling, A The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European prospective investigation into cancer and nutrition |
| title | The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European prospective investigation into cancer and nutrition |
| title_full | The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European prospective investigation into cancer and nutrition |
| title_fullStr | The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European prospective investigation into cancer and nutrition |
| title_full_unstemmed | The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European prospective investigation into cancer and nutrition |
| title_short | The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European prospective investigation into cancer and nutrition |
| title_sort | association between diet and serum concentrations of igf i igfbp 1 igfbp 2 and igfbp 3 in the european prospective investigation into cancer and nutrition |
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