An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein.
A series of seven monoclonal antibodies was produced against the T-lineage-specific 50 kd T11 sheep erythrocyte rosette (SRBC) receptor protein in order to define the function of the molecule. Three distinct epitopes were detected: T11(1), the SRBC binding site expressed on all T lymphocytes and thy...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1984
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| _version_ | 1797063213806780416 |
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| author | Meuer, S Hussey, R Fabbi, M Fox, D Acuto, O Fitzgerald, K Hodgdon, J Protentis, J Schlossman, S Reinherz, E |
| author_facet | Meuer, S Hussey, R Fabbi, M Fox, D Acuto, O Fitzgerald, K Hodgdon, J Protentis, J Schlossman, S Reinherz, E |
| author_sort | Meuer, S |
| collection | OXFORD |
| description | A series of seven monoclonal antibodies was produced against the T-lineage-specific 50 kd T11 sheep erythrocyte rosette (SRBC) receptor protein in order to define the function of the molecule. Three distinct epitopes were detected: T11(1), the SRBC binding site expressed on all T lymphocytes and thymocytes; T11(2), an epitope unrelated to the SRBC binding site but with a similar distribution; and T11(3), a neo-epitope expressed only upon T-cell activation. Simultaneous triggering of T11(2) and T11(3) epitopes by monoclonal antibodies induces T lymphocytes to proliferate and mediate their functional programs in the absence of antigen and/or antigen-presenting cells. This antigen-independent mode of triggering is distinct from that involving the T3-Ti antigen receptor complex and represents an alternate pathway of T-cell activation. Given that T11 is the earliest T-lineage surface glycoprotein to appear in thymic ontogeny and is thus expressed before T3-Ti, the former may be involved in clonal expansion and/or differentiation during early development. |
| first_indexed | 2024-03-06T20:56:36Z |
| format | Journal article |
| id | oxford-uuid:397a142d-7ed3-4375-b734-04128fad632a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:56:36Z |
| publishDate | 1984 |
| record_format | dspace |
| spelling | oxford-uuid:397a142d-7ed3-4375-b734-04128fad632a2022-03-26T13:55:44ZAn alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:397a142d-7ed3-4375-b734-04128fad632aEnglishSymplectic Elements at Oxford1984Meuer, SHussey, RFabbi, MFox, DAcuto, OFitzgerald, KHodgdon, JProtentis, JSchlossman, SReinherz, EA series of seven monoclonal antibodies was produced against the T-lineage-specific 50 kd T11 sheep erythrocyte rosette (SRBC) receptor protein in order to define the function of the molecule. Three distinct epitopes were detected: T11(1), the SRBC binding site expressed on all T lymphocytes and thymocytes; T11(2), an epitope unrelated to the SRBC binding site but with a similar distribution; and T11(3), a neo-epitope expressed only upon T-cell activation. Simultaneous triggering of T11(2) and T11(3) epitopes by monoclonal antibodies induces T lymphocytes to proliferate and mediate their functional programs in the absence of antigen and/or antigen-presenting cells. This antigen-independent mode of triggering is distinct from that involving the T3-Ti antigen receptor complex and represents an alternate pathway of T-cell activation. Given that T11 is the earliest T-lineage surface glycoprotein to appear in thymic ontogeny and is thus expressed before T3-Ti, the former may be involved in clonal expansion and/or differentiation during early development. |
| spellingShingle | Meuer, S Hussey, R Fabbi, M Fox, D Acuto, O Fitzgerald, K Hodgdon, J Protentis, J Schlossman, S Reinherz, E An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein. |
| title | An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein. |
| title_full | An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein. |
| title_fullStr | An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein. |
| title_full_unstemmed | An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein. |
| title_short | An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein. |
| title_sort | alternative pathway of t cell activation a functional role for the 50 kd t11 sheep erythrocyte receptor protein |
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