Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.

Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.

T-cell antigen receptor-induced signaling requires both ZAP-70 and Lck protein-tyrosine kinases. One essential function of Lck in this process is to phosphorylate ZAP-70 and up-regulate its catalytic activity. We have previously shown that after T-cell antigen receptor stimulation, Lck binds to ZAP-...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Pelosi, M, Di Bartolo, V, Mounier, V, Mège, D, Pascussi, J, Dufour, E, Blondel, A, Acuto, O
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	1999

Antzeko izenburuak

Role of the Src homology 2 domains and interdomain regions in ZAP-70 phosphorylation and enzymatic activity.
nork: Magistrelli, G, et al.
Argitaratua: (1999)

p56lck interacts via its src homology 2 domain with the ZAP-70 kinase.
nork: Duplay, P, et al.
Argitaratua: (1994)

Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling.
nork: Di Bartolo, V, et al.
Argitaratua: (1999)

INTERACTION OF HUMAN P56LCK SH2 DOMAIN WITH THE ZAP-70 TYROSINE KINASE
nork: Acuto, O, et al.
Argitaratua: (1994)

Tyrosine 315 determines optimal recruitment of ZAP-70 to the T cell antigen receptor.
nork: Di Bartolo, V, et al.
Argitaratua: (2002)

Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways.
nork: Mège, D, et al.
Argitaratua: (1996)

INTERACTION OF SYK AND ZAP-70 WITH P56LCK/CD4
nork: Acuto, O, et al.
Argitaratua: (1995)

T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase.
nork: Magnan, A, et al.
Argitaratua: (2001)

Activation of Zap-70 tyrosine kinase due to a structural rearrangement induced by tyrosine phosphorylation and/or ITAM binding.
nork: Visco, C, et al.
Argitaratua: (2000)

Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex.
nork: Thome, M, et al.
Argitaratua: (1995)

The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases.
nork: Arold, S, et al.
Argitaratua: (2001)

Quantitative phosphoproteome analysis unveils LAT as a modulator of CD3ζ and ZAP-70 tyrosine phosphorylation
nork: Salek, M, et al.
Argitaratua: (2013)

An improved retroviral gene transfer technique demonstrates inhibition of CD4-CD8- thymocyte development by kinase-inactive ZAP-70.
nork: Sugawara, T, et al.
Argitaratua: (1998)

The tyrosine kinase activity of p56lck is increased in human T cells activated via CD2.
nork: Danielian, S, et al.
Argitaratua: (1991)

Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells.
nork: Michel, F, et al.
Argitaratua: (1998)

Time-resolved multimodal analysis of Src Homology 2 (SH2) domain binding in signaling by receptor tyrosine kinases
nork: Oh, Dongmyung, et al.
Argitaratua: (2016)

The lymphocyte-specific protein tyrosine kinase p56lck is hyperphosphorylated on serine and tyrosine residues within minutes after activation via T cell receptor or CD2.
nork: Danielian, S, et al.
Argitaratua: (1989)

Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation.
nork: Dustin, L, et al.
Argitaratua: (1999)

Dephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor
nork: Goyette, J, et al.
Argitaratua: (2022)

Anti-peptide antibodies detect conformational changes of the inter-SH2 domain of ZAP-70 due to binding to the zeta chain and to intramolecular interactions.
nork: Grazioli, L, et al.
Argitaratua: (1998)

Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain
nork: Aprile, F, et al.
Argitaratua: (2013)

The p56lck SH2 domain mediates recruitment of CD8/p56lck to the activated T cell receptor/CD3/zeta complex.
nork: Thome, M, et al.
Argitaratua: (1996)

Binding, domain orientation, and dynamics of the Lck SH3-SH2 domain pair and comparison with other Src-family kinases.
nork: Hofmann, G, et al.
Argitaratua: (2005)

Intrinsic disorder in the T cell receptor creates cooperativity and controls ZAP70 binding
nork: Clemens, L, et al.
Argitaratua: (2020)

Interdomain multicast solutions guide /
nork: Adams, Brian
Argitaratua: (2002)

Both T cell receptor (TcR)-CD3 complex and CD2 increase the tyrosine kinase activity of p56lck. CD2 can mediate TcR-CD3-independent and CD45-dependent activation of p56lck.
nork: Danielian, S, et al.
Argitaratua: (1992)

SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis
nork: Lamar, John, et al.
Argitaratua: (2020)

Molecular mechanisms of Lck activity regulation in human peripheral blood T lymphocytes
nork: Irles, C, et al.
Argitaratua: (2004)

KITD816V induces SRC-mediated tyrosine phosphorylation of MITF and altered transcription program in melanoma
nork: Phung, B, et al.
Argitaratua: (2017)

The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway
nork: Sjolin-Goodfellow, Hanna, et al.
Argitaratua: (2016)

Lck and the nature of the T cell receptor trigger
nork: Davis, S, et al.
Argitaratua: (2011)

Lck and the nature of the T cell receptor trigger.
nork: Davis, S, et al.
Argitaratua: (2011)

The structure of an interdomain complex that regulates talin activity.
nork: Goult, B, et al.
Argitaratua: (2009)

Constitutively active Lck kinase in T cells drives antigen receptor signal transduction.
nork: Nika, K, et al.
Argitaratua: (2010)

Differential roles of Lck and Itk in T cell response to antigen recognition revealed by calcium imaging and electron microscopy.
nork: Donnadieu, E, et al.
Argitaratua: (2001)

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.
nork: Yokosuka, T, et al.
Argitaratua: (2005)

The steroidal lactone withaferin A impedes T-cell motility by inhibiting the kinase ZAP70 and subsequent kinome signaling
nork: Mobashar Hussain Urf Turabe Fazil, et al.
Argitaratua: (2022)

Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.
nork: Siggs, O, et al.
Argitaratua: (2007)

CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling.
nork: Irles, C, et al.
Argitaratua: (2003)

Interdomain association in fibronectin: insight into cryptic sites and fibrillogenesis.
nork: Vakonakis, I, et al.
Argitaratua: (2007)