Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.

Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.

T-cell antigen receptor-induced signaling requires both ZAP-70 and Lck protein-tyrosine kinases. One essential function of Lck in this process is to phosphorylate ZAP-70 and up-regulate its catalytic activity. We have previously shown that after T-cell antigen receptor stimulation, Lck binds to ZAP-...

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Bibliografiske detaljer
Main Authors:	Pelosi, M, Di Bartolo, V, Mounier, V, Mège, D, Pascussi, J, Dufour, E, Blondel, A, Acuto, O
Format:	Journal article
Sprog:	English
Udgivet:	1999

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