Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.
T-cell antigen receptor-induced signaling requires both ZAP-70 and Lck protein-tyrosine kinases. One essential function of Lck in this process is to phosphorylate ZAP-70 and up-regulate its catalytic activity. We have previously shown that after T-cell antigen receptor stimulation, Lck binds to ZAP-...
Հիմնական հեղինակներ: | Pelosi, M, Di Bartolo, V, Mounier, V, Mège, D, Pascussi, J, Dufour, E, Blondel, A, Acuto, O |
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Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
1999
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Նմանատիպ նյութեր
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Role of the Src homology 2 domains and interdomain regions in ZAP-70 phosphorylation and enzymatic activity.
: Magistrelli, G, և այլն
Հրապարակվել է: (1999) -
p56lck interacts via its src homology 2 domain with the ZAP-70 kinase.
: Duplay, P, և այլն
Հրապարակվել է: (1994) -
Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling.
: Di Bartolo, V, և այլն
Հրապարակվել է: (1999) -
INTERACTION OF HUMAN P56LCK SH2 DOMAIN WITH THE ZAP-70 TYROSINE KINASE
: Acuto, O, և այլն
Հրապարակվել է: (1994) -
INTERACTION OF SYK AND ZAP-70 WITH P56LCK/CD4
: Acuto, O, և այլն
Հրապարակվել է: (1995)