Conformational stability and activity of p73 require a second helix in the tetramerization domain.
p73 and p63, the two ancestral members of the p53 family, are involved in neurogenesis, epithelial stem cell maintenance and quality control of female germ cells. The highly conserved oligomerization domain (OD) of tumor suppressor p53 is essential for its biological functions, and its structure was...
Hlavní autoři: | Coutandin, D, Löhr, F, Niesen, F, Ikeya, T, Weber, T, Schäfer, B, Zielonka, E, Bullock, A, Yang, A, Güntert, P, Knapp, S, McKeon, F, Ou, H, Dötsch, V |
---|---|
Médium: | Journal article |
Jazyk: | English |
Vydáno: |
2009
|
Podobné jednotky
-
Conformational stability and activity of p73 require a second helix in the tetramerization domain.
Autor: Coutandin, D, a další
Vydáno: (2009) -
Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization.
Autor: Gebel, J, a další
Vydáno: (2016) -
DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer.
Autor: Deutsch, G, a další
Vydáno: (2011) -
RING tetramerization is required for nuclear body biogenesis and PML sumoylation
Autor: Pengran Wang, a další
Vydáno: (2018-03-01) -
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
Autor: Emma J. Petrie, a další
Vydáno: (2018-06-01)