An asymmetric Suzuki-Miyaura approach to prostaglandins: Synthesis of Tafluprost

We report the catalytic asymmetric synthesis of Tafluprost (1), a prostaglandin analogue. This synthesis demonstrates a new approach to prostaglandins involving symmetrization and desymmetrization of a racemic precursor to control the absolute and relative stereochemistry of the cyclopentyl core. Ke...

সম্পূর্ণ বিবরণ

গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Kučera, R, Goetzke, FW, Fletcher, SP
বিন্যাস: Journal article
ভাষা:English
প্রকাশিত: American Chemical Society 2020