An asymmetric Suzuki-Miyaura approach to prostaglandins: Synthesis of Tafluprost

We report the catalytic asymmetric synthesis of Tafluprost (1), a prostaglandin analogue. This synthesis demonstrates a new approach to prostaglandins involving symmetrization and desymmetrization of a racemic precursor to control the absolute and relative stereochemistry of the cyclopentyl core. Ke...

詳細記述

書誌詳細
主要な著者: Kučera, R, Goetzke, FW, Fletcher, SP
フォーマット: Journal article
言語:English
出版事項: American Chemical Society 2020