Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults
Elevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide association studies (GWAS) conducted predominantly in populations of European ancestry have identified >2,000 BP-associated loci, but other ancestries have been less well-studied. We conducted GWAS of...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2024
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| _version_ | 1811140326295863296 |
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| author | Pozarickij, A Gan, W Lin, K Clarke, R Fairhurst-Hunter, Z Koido, M Okada, Y Kamatani, Y Bennett, D Du, H Chen, Y Yang, L Avery, D Guo, Y Yu, M Schmidt Valle, D Lv, J Chen, J Peto, R Li, L Chen, Z Millwood, I Walters, R |
| author2 | China Kadoorie Biobank Collaborative Group |
| author_facet | China Kadoorie Biobank Collaborative Group Pozarickij, A Gan, W Lin, K Clarke, R Fairhurst-Hunter, Z Koido, M Okada, Y Kamatani, Y Bennett, D Du, H Chen, Y Yang, L Avery, D Guo, Y Yu, M Schmidt Valle, D Lv, J Chen, J Peto, R Li, L Chen, Z Millwood, I Walters, R |
| author_sort | Pozarickij, A |
| collection | OXFORD |
| description | Elevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide association studies (GWAS) conducted predominantly in populations of European ancestry have identified >2,000 BP-associated loci, but other ancestries have been less well-studied. We conducted GWAS of systolic, diastolic, pulse, and mean arterial BP in 100,453 Chinese adults. We identified 128 non-overlapping loci associated with one or more BP traits, including 74 newly-reported associations. Despite strong genetic correlations between populations, we identified appreciably higher heritability and larger variant effect sizes in Chinese compared with European or Japanese ancestry populations. Using instruments derived from these GWAS, multivariable Mendelian randomisation demonstrated that BP traits contribute differently to the causal associations of BP with CVD. In particular, only pulse pressure was independently causally associated with carotid plaque. These findings reinforce the need for studies in diverse populations to understand the genetic determinants of BP traits and their roles in disease risk. |
| first_indexed | 2024-09-25T04:20:12Z |
| format | Journal article |
| id | oxford-uuid:39aed6b3-2e28-43e5-ad03-307321de5ed9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:20:12Z |
| publishDate | 2024 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:39aed6b3-2e28-43e5-ad03-307321de5ed92024-08-05T12:38:42ZCausal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adultsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:39aed6b3-2e28-43e5-ad03-307321de5ed9EnglishSymplectic ElementsSpringer Nature2024Pozarickij, AGan, WLin, KClarke, RFairhurst-Hunter, ZKoido, MOkada, YKamatani, YBennett, DDu, HChen, YYang, LAvery, DGuo, YYu, MSchmidt Valle, DLv, JChen, JPeto, RLi, LChen, ZMillwood, IWalters, RChina Kadoorie Biobank Collaborative GroupElevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide association studies (GWAS) conducted predominantly in populations of European ancestry have identified >2,000 BP-associated loci, but other ancestries have been less well-studied. We conducted GWAS of systolic, diastolic, pulse, and mean arterial BP in 100,453 Chinese adults. We identified 128 non-overlapping loci associated with one or more BP traits, including 74 newly-reported associations. Despite strong genetic correlations between populations, we identified appreciably higher heritability and larger variant effect sizes in Chinese compared with European or Japanese ancestry populations. Using instruments derived from these GWAS, multivariable Mendelian randomisation demonstrated that BP traits contribute differently to the causal associations of BP with CVD. In particular, only pulse pressure was independently causally associated with carotid plaque. These findings reinforce the need for studies in diverse populations to understand the genetic determinants of BP traits and their roles in disease risk. |
| spellingShingle | Pozarickij, A Gan, W Lin, K Clarke, R Fairhurst-Hunter, Z Koido, M Okada, Y Kamatani, Y Bennett, D Du, H Chen, Y Yang, L Avery, D Guo, Y Yu, M Schmidt Valle, D Lv, J Chen, J Peto, R Li, L Chen, Z Millwood, I Walters, R Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults |
| title | Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults |
| title_full | Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults |
| title_fullStr | Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults |
| title_full_unstemmed | Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults |
| title_short | Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults |
| title_sort | causal relevance of different blood pressure traits on risk of cardiovascular diseases gwas and mendelian randomisation in 100 000 chinese adults |
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