Steering evolution with sequential therapy to prevent the emergence of bacterial antibiotic resistance

Steering evolution with sequential therapy to prevent the emergence of bacterial antibiotic resistance

The increasing rate of antibiotic resistance and slowing discovery of novel antibiotic treatments presents a growing threat to public health. Here, we consider a simple model of evolution in asexually reproducing populations which considers adaptation as a biased random walk on a fitness landscape....

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Nichol, D, Jeavons, P, Fletcher, A, Bonomo, R, Maini, P, Paul, J, Gatenby, R, Anderson, A, Scott, J
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	Public Library of Science 2015

Eitemau Tebyg

Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance.
gan: Daniel Nichol, et al.
Cyhoeddwyd: (2015-09-01)

Antibiotic collateral sensitivity is contingent on the repeatability of evolution
gan: Nichol, D, et al.
Cyhoeddwyd: (2019)

Antibiotic collateral sensitivity is contingent on the repeatability of evolution
gan: Daniel Nichol, et al.
Cyhoeddwyd: (2019-01-01)

The evolution of strategy in bacterial warfare via the regulation of bacteriocins and antibiotics
gan: Niehus, R, et al.
Cyhoeddwyd: (2021)

Comparative study between discrete and continuum models for the evolution of competing phenotype-structured cell populations in dynamical environments
gan: Ardaseva, A, et al.
Cyhoeddwyd: (2020)

Episodic, transient systemic acidosis delays evolution of the malignant phenotype: Possible mechanism for cancer prevention by increased physical activity
gan: Smallbone, K, et al.
Cyhoeddwyd: (2010)

Episodic, transient systemic acidosis delays evolution of the malignant phenotype: Possible mechanism for cancer prevention by increased physical activity.
gan: Smallbone, K, et al.
Cyhoeddwyd: (2010)

The evolution of strategy in bacterial warfare via the regulation of bacteriocins and antibiotics
gan: Rene Niehus, et al.
Cyhoeddwyd: (2021-09-01)

Bacterial evolution of antibiotic hypersensitivity
gan: Viktória Lázár, et al.
Cyhoeddwyd: (2013-10-01)

Mathematical oncology: cancer summed up.
gan: Gatenby, R, et al.
Cyhoeddwyd: (2003)

Some mathematical modelling challenges and approaches in cancer
gan: Maini, P, et al.
Cyhoeddwyd: (2006)

Modelling a new angle on understanding cancer
gan: Gatenby, R, et al.
Cyhoeddwyd: (2002)

Mathematical oncology: Cancer summed up [Concepts article]
gan: Gatenby, R, et al.
Cyhoeddwyd: (2003)

The evolution of antibiotic resistance in bacterial colonies
gan: Frost, I
Cyhoeddwyd: (2017)

Modified Antibiotic Adjuvant Ratios Can Slow and Steer the Evolution of Resistance: Co-amoxiclav as a Case Study
gan: Richard C. Allen, et al.
Cyhoeddwyd: (2019-10-01)

In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host
gan: A. Launay, et al.
Cyhoeddwyd: (2021-07-01)

Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer.
gan: Gatenby, R, et al.
Cyhoeddwyd: (2007)

Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer
gan: Gatenby, R, et al.
Cyhoeddwyd: (2007)

SEQUENTIAL AND SYNCHRONOUS SKIN PATTERN-FORMATION
gan: Cruywagen, G, et al.
Cyhoeddwyd: (1993)

Sequential and synchronous skin pattern formation
gan: Cruywagen, G, et al.
Cyhoeddwyd: (1993)

Minimizing treatment-induced emergence of antibiotic resistance in bacterial infections
gan: Stracy, M, et al.
Cyhoeddwyd: (2022)

Inferring tumour proliferative organisation from phylogenetic tree measures in a computational model
gan: Maini, P, et al.
Cyhoeddwyd: (2019)

Stochasticity in the genotype-phenotype map: Implications for the robustness and persistence of bet-hedging
gan: Nichol, D, et al.
Cyhoeddwyd: (2016)

Emerging bacterial resistance to antibiotics – fighting a losing battle !
gan: J. Ashraful Haq
Cyhoeddwyd: (2009-01-01)

An envelope method for analyzing sequential pattern formation
gan: Cruywagen, G, et al.
Cyhoeddwyd: (2000)

An envelope method for analysing sequential pattern formation
gan: Cruywagen, G, et al.
Cyhoeddwyd: (2000)

Episodic, transient systemic acidosis delays evolution of the malignant phenotype: Possible mechanism for cancer prevention by increased physical activity
gan: Maini Philip K, et al.
Cyhoeddwyd: (2010-04-01)

A mathematical dissection of the adaptation of cell populations to fluctuating oxygen levels
gan: Ardaseva, A, et al.
Cyhoeddwyd: (2020)

Evolutionary dynamics of competing phenotype-structured populations in periodically fluctuating environments
gan: Ardaseva, A, et al.
Cyhoeddwyd: (2019)

Analysis of tumor as an inverse problem provides a novel theoretical framework for understanding tumor biology and therapy
gan: Gatenby, R, et al.
Cyhoeddwyd: (2002)

Mathematical modelling of tumour acidity.
gan: Smallbone, K, et al.
Cyhoeddwyd: (2008)

Mathematical modelling of tumour acidity
gan: Smallbone, K, et al.
Cyhoeddwyd: (2008)

Analysis of tumor as an inverse problem provides a novel theoretical framework for understanding tumor biology and therapy
gan: Gatenby, R, et al.
Cyhoeddwyd: (2002)

Modelling of tumour metabolism
gan: Maini, P, et al.
Cyhoeddwyd: (2010)

Promiscuity of response regulators for thioredoxin steers bacterial virulence
gan: Ju-Sim Kim, et al.
Cyhoeddwyd: (2022-10-01)

Sequential pattern formation in a model for skin morphogenesis.
gan: Cruywagen, G, et al.
Cyhoeddwyd: (1992)

Sequential pattern formation in a model for skin morphogenesis
gan: Cruywagen, G, et al.
Cyhoeddwyd: (1992)

Tumour angiogenesis: the gap between theory and experiments.
gan: Schofield, J, et al.
Cyhoeddwyd: (2011)

Tumour angiogenesis: The gap between theory and experiment
gan: Schofield, J, et al.
Cyhoeddwyd: (2011)

Evolution of antibiotic resistance by human and bacterial niche construction.
gan: Boni, M, et al.
Cyhoeddwyd: (2005)