Steering evolution with sequential therapy to prevent the emergence of bacterial antibiotic resistance

Steering evolution with sequential therapy to prevent the emergence of bacterial antibiotic resistance

The increasing rate of antibiotic resistance and slowing discovery of novel antibiotic treatments presents a growing threat to public health. Here, we consider a simple model of evolution in asexually reproducing populations which considers adaptation as a biased random walk on a fitness landscape....

书目详细资料
Main Authors:	Nichol, D, Jeavons, P, Fletcher, A, Bonomo, R, Maini, P, Paul, J, Gatenby, R, Anderson, A, Scott, J
格式:	Journal article
语言:	English
出版:	Public Library of Science 2015

相似书籍

Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance.
由: Daniel Nichol, et al.
出版: (2015-09-01)

Antibiotic collateral sensitivity is contingent on the repeatability of evolution
由: Nichol, D, et al.
出版: (2019)

Antibiotic collateral sensitivity is contingent on the repeatability of evolution
由: Daniel Nichol, et al.
出版: (2019-01-01)

The evolution of strategy in bacterial warfare via the regulation of bacteriocins and antibiotics
由: Niehus, R, et al.
出版: (2021)

Comparative study between discrete and continuum models for the evolution of competing phenotype-structured cell populations in dynamical environments
由: Ardaseva, A, et al.
出版: (2020)

Episodic, transient systemic acidosis delays evolution of the malignant phenotype: Possible mechanism for cancer prevention by increased physical activity
由: Smallbone, K, et al.
出版: (2010)

Episodic, transient systemic acidosis delays evolution of the malignant phenotype: Possible mechanism for cancer prevention by increased physical activity.
由: Smallbone, K, et al.
出版: (2010)

The evolution of strategy in bacterial warfare via the regulation of bacteriocins and antibiotics
由: Rene Niehus, et al.
出版: (2021-09-01)

Bacterial evolution of antibiotic hypersensitivity
由: Viktória Lázár, et al.
出版: (2013-10-01)

Mathematical oncology: cancer summed up.
由: Gatenby, R, et al.
出版: (2003)

Some mathematical modelling challenges and approaches in cancer
由: Maini, P, et al.
出版: (2006)

Modelling a new angle on understanding cancer
由: Gatenby, R, et al.
出版: (2002)

Mathematical oncology: Cancer summed up [Concepts article]
由: Gatenby, R, et al.
出版: (2003)

The evolution of antibiotic resistance in bacterial colonies
由: Frost, I
出版: (2017)

Modified Antibiotic Adjuvant Ratios Can Slow and Steer the Evolution of Resistance: Co-amoxiclav as a Case Study
由: Richard C. Allen, et al.
出版: (2019-10-01)

In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host
由: A. Launay, et al.
出版: (2021-07-01)

Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer.
由: Gatenby, R, et al.
出版: (2007)

Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer
由: Gatenby, R, et al.
出版: (2007)

SEQUENTIAL AND SYNCHRONOUS SKIN PATTERN-FORMATION
由: Cruywagen, G, et al.
出版: (1993)

Sequential and synchronous skin pattern formation
由: Cruywagen, G, et al.
出版: (1993)

Minimizing treatment-induced emergence of antibiotic resistance in bacterial infections
由: Stracy, M, et al.
出版: (2022)

Inferring tumour proliferative organisation from phylogenetic tree measures in a computational model
由: Maini, P, et al.
出版: (2019)

Stochasticity in the genotype-phenotype map: Implications for the robustness and persistence of bet-hedging
由: Nichol, D, et al.
出版: (2016)

Emerging bacterial resistance to antibiotics – fighting a losing battle !
由: J. Ashraful Haq
出版: (2009-01-01)

An envelope method for analyzing sequential pattern formation
由: Cruywagen, G, et al.
出版: (2000)

An envelope method for analysing sequential pattern formation
由: Cruywagen, G, et al.
出版: (2000)

Episodic, transient systemic acidosis delays evolution of the malignant phenotype: Possible mechanism for cancer prevention by increased physical activity
由: Maini Philip K, et al.
出版: (2010-04-01)

A mathematical dissection of the adaptation of cell populations to fluctuating oxygen levels
由: Ardaseva, A, et al.
出版: (2020)

Evolutionary dynamics of competing phenotype-structured populations in periodically fluctuating environments
由: Ardaseva, A, et al.
出版: (2019)

Analysis of tumor as an inverse problem provides a novel theoretical framework for understanding tumor biology and therapy
由: Gatenby, R, et al.
出版: (2002)

Mathematical modelling of tumour acidity.
由: Smallbone, K, et al.
出版: (2008)

Mathematical modelling of tumour acidity
由: Smallbone, K, et al.
出版: (2008)

Analysis of tumor as an inverse problem provides a novel theoretical framework for understanding tumor biology and therapy
由: Gatenby, R, et al.
出版: (2002)

Modelling of tumour metabolism
由: Maini, P, et al.
出版: (2010)

Promiscuity of response regulators for thioredoxin steers bacterial virulence
由: Ju-Sim Kim, et al.
出版: (2022-10-01)

Sequential pattern formation in a model for skin morphogenesis.
由: Cruywagen, G, et al.
出版: (1992)

Sequential pattern formation in a model for skin morphogenesis
由: Cruywagen, G, et al.
出版: (1992)

Tumour angiogenesis: the gap between theory and experiments.
由: Schofield, J, et al.
出版: (2011)

Tumour angiogenesis: The gap between theory and experiment
由: Schofield, J, et al.
出版: (2011)

Evolution of antibiotic resistance by human and bacterial niche construction.
由: Boni, M, et al.
出版: (2005)