Steering evolution with sequential therapy to prevent the emergence of bacterial antibiotic resistance
The increasing rate of antibiotic resistance and slowing discovery of novel antibiotic treatments presents a growing threat to public health. Here, we consider a simple model of evolution in asexually reproducing populations which considers adaptation as a biased random walk on a fitness landscape....
| Main Authors: | , , , , , , , , |
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| 格式: | Journal article |
| 语言: | English |
| 出版: |
Public Library of Science
2015
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