N-acetyl-beta-D-glucopyranosylamine: a potent T-state inhibitor of glycogen phosphorylase. A comparison with alpha-D-glucose.

N-acetyl-beta-D-glucopyranosylamine: a potent T-state inhibitor of glycogen phosphorylase. A comparison with alpha-D-glucose.

Structure-based drug design has led to the discovery of a number of glucose analogue inhibitors of glycogen phosphorylase that have an increased affinity compared to alpha-D-glucose (Ki = 1.7 mM). The best inhibitor in the class of N-acyl derivatives of beta-D-glucopyranosylamine, N-acetyl-beta-D-gl...

書目詳細資料
Main Authors:	Oikonomakos, N, Kontou, M, Zographos, SE, Watson, K, Johnson, L, Bichard, C, Fleet, G, Acharya, K
格式:	Journal article
語言:	English
出版:	1995

相似書籍

Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase.
由: Watson, K, et al.
出版: (2005)

The design of potential antidiabetic drugs: experimental investigation of a number of beta-D-glucose analogue inhibitors of glycogen phosphorylase.
由: Oikonomakos, N, et al.
出版: (1994)

Design of inhibitors of glycogen phosphorylase: a study of alpha- and beta-C-glucosides and 1-thio-beta-D-glucose compounds.
由: Watson, K, et al.
出版: (1994)

POTENT INHIBITION OF GLYCOGEN-PHOSPHORYLASE BY A SPIROHYDANTOIN OF GLUCOPYRANOSE - FIRST PYRANOSE ANALOGS OF HYDANTOCIDIN
由: Bichard, C, et al.
出版: (1995)

INHIBITORS OF GLYCOGEN-PHOSPHORYLASE
由: Bichard, C, et al.
出版: (1994)

Stereospecific synthesis of spirohydantoins of beta-glucopyranose: Inhibitors of glycogen phosphorylase
由: Krulle, T, et al.
出版: (1997)

Glucopyranose spirohydantoins: Specific inhibitors of glycogen phosphorylase
由: delaFuente, C, et al.
出版: (1997)

Glucose analogue inhibitors of glycogen phosphorylase: from crystallographic analysis to drug prediction using GRID force-field and GOLPE variable selection.
由: Watson, K, et al.
出版: (1995)

Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure.
由: Tsitsanou, K, et al.
出版: (1999)

GLUCOSE ANALOG INHIBITORS OF GLYCOGEN-PHOSPHORYLASE
由: Johnson, L, et al.
出版: (1994)

The binding of beta-glycerophosphate to glycogen phosphorylase b in the crystal.
由: Oikonomakos, N, et al.
出版: (1989)

Triazole carboxylic acids as anionic sugar mimics? Inhibition of glycogen phosphorylase by a D-glucotriazole carboxylate
由: Krulle, T, et al.
出版: (1997)

SPECIFIC-INHIBITION OF GLYCOGEN-PHOSPHORYLASE BY A SPIRODIKETOPIPERAZINE AT THE ANOMERIC POSITION OF GLUCOPYRANOSE
由: Krulle, T, et al.
出版: (1995)

Uridine(5')diphospho(1)-alpha-D-glucose. A binding study to glycogen phosphorylase b in the crystal.
由: Oikonomakos, N, et al.
出版: (1988)

Phosphate-recognition sites in catalysis and control of glycogen phosphorylase b.
由: Johnson, L, et al.
出版: (1987)

Catalysis in the crystal: synchrotron radiation studies with glycogen phosphorylase b.
由: Hajdu, J, et al.
出版: (1987)

Glucose analogue inhibitors of glycogen phosphorylase: the design of potential drugs for diabetes.
由: Martin, J, et al.
出版: (1991)

The structure of phosphorylase kinase holoenzyme at 9.9 angstroms resolution and location of the catalytic subunit and the substrate glycogen phosphorylase.
由: Vénien-Bryan, C, et al.
出版: (2009)

Structural changes in glycogen phosphorylase induced by phosphorylation.
由: Sprang, SR, et al.
出版: (1988)

Pyridoxal phosphate site in glycogen phosphorylase b: structure in native enzyme and in three derivatives with modified cofactors.
由: Oikonomakos, N, et al.
出版: (1987)

Studies on the glycogen phosphorylase system
由: Busby, S
出版: (1975)

The structure of a glycogen phosphorylase glucopyranose spirohydantoin complex at 1.8 A resolution and 100 K: the role of the water structure and its contribution to binding.
由: Gregoriou, M, et al.
出版: (1998)

Towards time-resolved diffraction studies with glycogen phosphorylase.
由: Duke, E, et al.
出版: (1991)

TOWARDS TIME-RESOLVED DIFFRACTION STUDIES WITH GLYCOGEN-PHOSPHORYLASE
由: Duke, E, et al.
出版: (1991)

TOWARDS TIME-RESOLVED DIFFRACTION STUDIES WITH GLYCOGEN-PHOSPHORYLASE
由: Duke, E, et al.
出版: (1991)

C-(β-D-Glucopyranosyl) heterocycles as potential glycogen phosphorylase inhibitors
由: Zsuzsa Hadady, et al.
出版: (2004-03-01)

Cryocrystallographic and mechanistic studies on glycogen phosphorylase
由: Mitchell, E
出版: (1994)

NMR and MS study of the formation of β-D-glucopyranosylamine uronic acid in aqueous solution
由: Ghadban, Ali, et al.
出版: (2014)

Effects of C-1-substituted glucose analogue on the activation states of glycogen synthase and glycogen phosphorylase in rat hepatocytes.
由: Board, M, et al.
出版: (1995)

GLYCOGEN PHOSPHORYLASE-B - THE MOLECULAR ANATOMY OF A LARGE REGULATORY ENZYME
由: Sansom, M, et al.
出版: (1985)

Substrate-cofactor interactions for glycogen phosphorylase b: a binding study in the crystal with heptenitol and heptulose 2-phosphate.
由: McLaughlin, P, et al.
出版: (1984)

Time-resolved structural studies on catalysis in the crystal with glycogen phosphorylase b.
由: Hajdu, J, et al.
出版: (1986)

The role of glycogen phosphorylase in glycogen biogenesis in skeletal muscle after exercise
由: Abram Katz
出版: (2023-03-01)

On the promise of glycogen phosphorylase inhibition in acute inflammation
由: Aarooran Sivakumaran Durairaj, et al.
出版: (2021-03-01)

Transcriptional regulation of rat brain glycogen phosphorylase
由: Hamprecht Bernd, et al.
出版: (2007-03-01)

Comparison of AMP and NADH binding to glycogen phosphorylase b.
由: Stura, E, et al.
出版: (1983)

Mitochondrial Redox Status Regulates Glycogen Metabolism via Glycogen Phosphorylase Activity
由: Ikko Sakamoto, et al.
出版: (2024-11-01)

Physicochemical and Spectroscopic Characterization of Glycogen and Glycogen Phosphorylase <i>b</i> Complexes
由: Pandora Karakousi, et al.
出版: (2024-07-01)

Three-dimensional structure of phosphorylase kinase at 22 A resolution and its complex with glycogen phosphorylase b.
由: Vénien-Bryan, C, et al.
出版: (2002)

X-ray crystallographic studies of glycogen phosphorylase b
由: Wild, D, et al.
出版: (1981)