N-acetyl-beta-D-glucopyranosylamine: a potent T-state inhibitor of glycogen phosphorylase. A comparison with alpha-D-glucose.

N-acetyl-beta-D-glucopyranosylamine: a potent T-state inhibitor of glycogen phosphorylase. A comparison with alpha-D-glucose.

Structure-based drug design has led to the discovery of a number of glucose analogue inhibitors of glycogen phosphorylase that have an increased affinity compared to alpha-D-glucose (Ki = 1.7 mM). The best inhibitor in the class of N-acyl derivatives of beta-D-glucopyranosylamine, N-acetyl-beta-D-gl...

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Dettagli Bibliografici
Autori principali:	Oikonomakos, N, Kontou, M, Zographos, SE, Watson, K, Johnson, L, Bichard, C, Fleet, G, Acharya, K
Natura:	Journal article
Lingua:	English
Pubblicazione:	1995

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