Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.

IGF-I is considered a primary inhibitor of GH secretion. Insulin may also play an important role in regulating GH levels because insulin, like IGF-I, can suppress GH synthesis and release in primary pituitary cell cultures and insulin is negatively correlated with GH levels in vivo. However, underst...

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Những tác giả chính: Gahete, MD, Córdoba-Chacón, J, Lin, Q, Brüning, J, Kahn, C, Castaño, J, Christian, H, Luque, R, Kineman, R
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2013