Cytokines as therapeutics and targets of therapeutics
Cytokine research has spawned the introduction of new therapies that have revolutionized the treatment of many important diseases. These therapeutic advances have resulted from two very different strategies. The first therapeutic strategy embodies the administration of purified, recombinant cytokine...
| Main Authors: | , |
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| Format: | Journal article |
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2006
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| _version_ | 1797063294602706944 |
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| author | Vilček, J Feldmann, M |
| author_facet | Vilček, J Feldmann, M |
| author_sort | Vilček, J |
| collection | OXFORD |
| description | Cytokine research has spawned the introduction of new therapies that have revolutionized the treatment of many important diseases. These therapeutic advances have resulted from two very different strategies. The first therapeutic strategy embodies the administration of purified, recombinant cytokines. The second relies on the administration of therapeutics that inhibit the harmful effects of upregulated, endogenous cytokines. Examples of successful cytokine therapeutics include hematopoietic growth factors (colony stimulating factors) and interferons. Prime examples of cytokine antagonists that have profoundly altered the treatment of some inflammatory disorders are agents that inhibit the effects of tumor necrosis factor (TNF). In this article, we highlight some of the studies that have been responsible for the introduction of cytokine and anti-cytokine therapies, with emphasis on the development of interferons and anti-TNF agents. |
| first_indexed | 2024-03-06T20:57:46Z |
| format | Journal article |
| id | oxford-uuid:39d85d6c-c4a5-4e1b-94e8-14c702975d0d |
| institution | University of Oxford |
| last_indexed | 2024-03-06T20:57:46Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:39d85d6c-c4a5-4e1b-94e8-14c702975d0d2022-03-26T13:57:57ZCytokines as therapeutics and targets of therapeuticsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:39d85d6c-c4a5-4e1b-94e8-14c702975d0dSymplectic Elements at Oxford2006Vilček, JFeldmann, MCytokine research has spawned the introduction of new therapies that have revolutionized the treatment of many important diseases. These therapeutic advances have resulted from two very different strategies. The first therapeutic strategy embodies the administration of purified, recombinant cytokines. The second relies on the administration of therapeutics that inhibit the harmful effects of upregulated, endogenous cytokines. Examples of successful cytokine therapeutics include hematopoietic growth factors (colony stimulating factors) and interferons. Prime examples of cytokine antagonists that have profoundly altered the treatment of some inflammatory disorders are agents that inhibit the effects of tumor necrosis factor (TNF). In this article, we highlight some of the studies that have been responsible for the introduction of cytokine and anti-cytokine therapies, with emphasis on the development of interferons and anti-TNF agents. |
| spellingShingle | Vilček, J Feldmann, M Cytokines as therapeutics and targets of therapeutics |
| title | Cytokines as therapeutics and targets of therapeutics |
| title_full | Cytokines as therapeutics and targets of therapeutics |
| title_fullStr | Cytokines as therapeutics and targets of therapeutics |
| title_full_unstemmed | Cytokines as therapeutics and targets of therapeutics |
| title_short | Cytokines as therapeutics and targets of therapeutics |
| title_sort | cytokines as therapeutics and targets of therapeutics |
| work_keys_str_mv | AT vilcekj cytokinesastherapeuticsandtargetsoftherapeutics AT feldmannm cytokinesastherapeuticsandtargetsoftherapeutics |