Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.

Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.

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Human carbonyl reductase is a member of the short-chain dehydrogenase/reductase (SDR) protein superfamily and is known to play an important role in the detoxification of xenobiotics bearing a carbonyl group. The two monomeric NADPH-dependent human isoforms of cytosolic carbonyl reductase CBR1 and CB...

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Manylion Llyfryddiaeth
Prif Awduron: El-Hawari, Y, Favia, A, Pilka, E, Kisiela, M, Oppermann, U, Martin, H, Maser, E
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 2009
Pynciau:
DNA Primers
Base Sequence
chemistry
Models, Molecular
Kinetics
Substrate Specificity
genetics
Humans
Sequence Homology, Amino Acid
Binding Sites
DNA, Complementary
Alcohol Oxidoreductases
Amino Acid Sequence
metabolism
Mutagenesis, Site-Directed
isolation and purification
Biocatalysis
Molecular Sequence Data

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