Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.

Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.

Visa andra versioner (1)

Human carbonyl reductase is a member of the short-chain dehydrogenase/reductase (SDR) protein superfamily and is known to play an important role in the detoxification of xenobiotics bearing a carbonyl group. The two monomeric NADPH-dependent human isoforms of cytosolic carbonyl reductase CBR1 and CB...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän: El-Hawari, Y, Favia, A, Pilka, E, Kisiela, M, Oppermann, U, Martin, H, Maser, E
Materialtyp: Journal article
Språk:English
Publicerad: 2009
Ämnen:
DNA Primers
Base Sequence
chemistry
Models, Molecular
Kinetics
Substrate Specificity
genetics
Humans
Sequence Homology, Amino Acid
Binding Sites
DNA, Complementary
Alcohol Oxidoreductases
Amino Acid Sequence
metabolism
Mutagenesis, Site-Directed
isolation and purification
Biocatalysis
Molecular Sequence Data

Liknande verk