The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1.
CD8(+) T-cell responses are an essential antiviral host defense in persistent viral infections, and their sustained effectiveness is thought to be critically dependent on CD4(+) T-helper cells. To determine the relationship between HIV-1-induced CD4(+) T-cell depletion and hepatitis C virus (HCV)-sp...
| Main Authors: | , , , , , , , , , , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
2005
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| _version_ | 1826267693380009984 |
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| author | Kim, A Lauer, G Ouchi, K Addo, M Lucas, M Schulze Zur Wiesch, J Timm, J Boczanowski, M Duncan, J Wurcel, A Casson, D Chung, RT Draenert, R Klenerman, P Walker, B |
| author_facet | Kim, A Lauer, G Ouchi, K Addo, M Lucas, M Schulze Zur Wiesch, J Timm, J Boczanowski, M Duncan, J Wurcel, A Casson, D Chung, RT Draenert, R Klenerman, P Walker, B |
| author_sort | Kim, A |
| collection | OXFORD |
| description | CD8(+) T-cell responses are an essential antiviral host defense in persistent viral infections, and their sustained effectiveness is thought to be critically dependent on CD4(+) T-helper cells. To determine the relationship between HIV-1-induced CD4(+) T-cell depletion and hepatitis C virus (HCV)-specific CD8(+) T-cell responses during viral persistence, we studied 103 persons positive for HCV, 74 coinfected with HIV-1. CD8(+) T-cell responses to the entire HCV polyprotein were determined by using an interferon-gamma enzyme-linked immunospot (ELISpot) assay. Although HIV-1 infection by itself was not associated with a diminished HCV-specific response, HIV-1-associated CD4(+) depletion was associated with significantly lower HCV-specific CD8(+) T cells (R = 0.48, P < .0001). In contrast, declining CD4(+) counts over the same range were not associated with diminished Epstein-Barr virus (EBV)- (R = 0.19, P = .31) or HIV-1-specific (R = -0.13, P = .60) CD8(+) T-cell responses in persons infected with all viruses. These data indicate that frequencies of circulating HCV-specific CD8(+) T-cell responses are sensitive to absolute CD4(+) T-cell counts and provide a possible explanation for the accelerated HCV disease course in persons coinfected with HIV-1 and HCV. |
| first_indexed | 2024-03-06T20:58:05Z |
| format | Journal article |
| id | oxford-uuid:39f1baab-df81-4670-89c9-766ef821cbbc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:58:05Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:39f1baab-df81-4670-89c9-766ef821cbbc2022-03-26T13:58:35ZThe magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:39f1baab-df81-4670-89c9-766ef821cbbcEnglishSymplectic Elements at Oxford2005Kim, ALauer, GOuchi, KAddo, MLucas, MSchulze Zur Wiesch, JTimm, JBoczanowski, MDuncan, JWurcel, ACasson, DChung, RTDraenert, RKlenerman, PWalker, BCD8(+) T-cell responses are an essential antiviral host defense in persistent viral infections, and their sustained effectiveness is thought to be critically dependent on CD4(+) T-helper cells. To determine the relationship between HIV-1-induced CD4(+) T-cell depletion and hepatitis C virus (HCV)-specific CD8(+) T-cell responses during viral persistence, we studied 103 persons positive for HCV, 74 coinfected with HIV-1. CD8(+) T-cell responses to the entire HCV polyprotein were determined by using an interferon-gamma enzyme-linked immunospot (ELISpot) assay. Although HIV-1 infection by itself was not associated with a diminished HCV-specific response, HIV-1-associated CD4(+) depletion was associated with significantly lower HCV-specific CD8(+) T cells (R = 0.48, P < .0001). In contrast, declining CD4(+) counts over the same range were not associated with diminished Epstein-Barr virus (EBV)- (R = 0.19, P = .31) or HIV-1-specific (R = -0.13, P = .60) CD8(+) T-cell responses in persons infected with all viruses. These data indicate that frequencies of circulating HCV-specific CD8(+) T-cell responses are sensitive to absolute CD4(+) T-cell counts and provide a possible explanation for the accelerated HCV disease course in persons coinfected with HIV-1 and HCV. |
| spellingShingle | Kim, A Lauer, G Ouchi, K Addo, M Lucas, M Schulze Zur Wiesch, J Timm, J Boczanowski, M Duncan, J Wurcel, A Casson, D Chung, RT Draenert, R Klenerman, P Walker, B The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1. |
| title | The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1. |
| title_full | The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1. |
| title_fullStr | The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1. |
| title_full_unstemmed | The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1. |
| title_short | The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1. |
| title_sort | magnitude and breadth of hepatitis c virus specific cd8 t cells depend on absolute cd4 t cell count in individuals coinfected with hiv 1 |
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