Primary microRNA transcripts are processed co-transcriptionally.

Primary microRNA transcripts are processed co-transcriptionally.

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microRNAs (miRNAs) are generated from long primary (pri-) RNA polymerase II (Pol II)-derived transcripts by two RNase III processing reactions: Drosha cleavage of nuclear pri-miRNAs and Dicer cleavage of cytoplasmic pre-miRNAs. Here we show that Drosha cleavage occurs during transcription acting on...

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Bibliographic Details
Main Authors:	Morlando, M, Ballarino, M, Gromak, N, Pagano, F, Bozzoni, I, Proudfoot, N
Format:	Journal article
Language:	English
Published:	2008

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