Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes.

Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes.

ATP-sensitive potassium (K(ATP)) channels, composed of pore-forming Kir6.2 and regulatory sulphonylurea receptor (SUR) subunits, play an essential role in insulin secretion from pancreatic beta cells. Binding of ATP to Kir6.2 inhibits, whereas interaction of Mg-nucleotides with SUR, activates the ch...

Podrobná bibliografie
Hlavní autoři:	Girard, C, Shimomura, K, Proks, P, Absalom, N, Castano, L, Perez de Nanclares, G, Ashcroft, F
Médium:	Journal article
Jazyk:	English
Vydáno:	2006

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