The use of carboxymethylcellulose gel to increase non-viral gene transfer in mouse airways.

The use of carboxymethylcellulose gel to increase non-viral gene transfer in mouse airways.

We have assessed whether viscoelastic gels known to inhibit mucociliary clearance can increase lipid-mediated gene transfer. Methylcellulose or carboxymethylcellulose (0.25-1.5%) was mixed with complexes of the cationic lipid GL67A and plasmids encoding luciferase and perfused onto the nasal epithel...

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Main Authors:	Griesenbach, U, Meng, C, Farley, R, Wasowicz, M, Munkonge, F, Chan, M, Stoneham, C, Sumner-Jones, S, Pringle, I, Gill, DR, Hyde, S, Stevenson, B, Holder, E, Ban, H, Hasegawa, M, Cheng, S, Scheule, R, Sinn, P, McCray, P, Alton, E
Format:	Journal article
Language:	English
Published:	2010

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