Structure and association of ATP-binding cassette transporter nucleotide-binding domains
ATP-binding cassette transporters are responsible for the uptake and efflux of a multitude of substances across both eukaryotic and prokaryotic membranes. Members of this family of proteins are involved in diverse physiological processes including antigen presentation, drug efflux from cancer cells,...
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| Fformat: | Journal article |
| Iaith: | English |
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Elsevier
2002
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| Pynciau: |
| _version_ | 1826267732212973568 |
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| author | Kerr, I |
| author_facet | Kerr, I |
| author_sort | Kerr, I |
| collection | OXFORD |
| description | ATP-binding cassette transporters are responsible for the uptake and efflux of a multitude of substances across both eukaryotic and prokaryotic membranes. Members of this family of proteins are involved in diverse physiological processes including antigen presentation, drug efflux from cancer cells, bacterial nutrient uptake and cystic fibrosis. In order to understand more completely the role of these multidomain transporters an integrated approach combining structural, pharmacological and biochemical methods is being adopted. Recent structural data have been obtained on the cytoplasmic, nucleotide-binding domains of prokaryotic ABC transporters. This review evaluates both these data and the conflicting implications they have for domain communication in ABC transporters. Areas of biochemical research that attempt to resolve these conflicts will be discussed. |
| first_indexed | 2024-03-06T20:58:42Z |
| format | Journal article |
| id | oxford-uuid:3a23b5d9-5b37-41cb-b24a-7de4222bd848 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:58:42Z |
| publishDate | 2002 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:3a23b5d9-5b37-41cb-b24a-7de4222bd8482022-03-26T13:59:45ZStructure and association of ATP-binding cassette transporter nucleotide-binding domainsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3a23b5d9-5b37-41cb-b24a-7de4222bd848BiochemistryEnglishOxford University Research Archive - ValetElsevier2002Kerr, IATP-binding cassette transporters are responsible for the uptake and efflux of a multitude of substances across both eukaryotic and prokaryotic membranes. Members of this family of proteins are involved in diverse physiological processes including antigen presentation, drug efflux from cancer cells, bacterial nutrient uptake and cystic fibrosis. In order to understand more completely the role of these multidomain transporters an integrated approach combining structural, pharmacological and biochemical methods is being adopted. Recent structural data have been obtained on the cytoplasmic, nucleotide-binding domains of prokaryotic ABC transporters. This review evaluates both these data and the conflicting implications they have for domain communication in ABC transporters. Areas of biochemical research that attempt to resolve these conflicts will be discussed. |
| spellingShingle | Biochemistry Kerr, I Structure and association of ATP-binding cassette transporter nucleotide-binding domains |
| title | Structure and association of ATP-binding cassette transporter nucleotide-binding domains |
| title_full | Structure and association of ATP-binding cassette transporter nucleotide-binding domains |
| title_fullStr | Structure and association of ATP-binding cassette transporter nucleotide-binding domains |
| title_full_unstemmed | Structure and association of ATP-binding cassette transporter nucleotide-binding domains |
| title_short | Structure and association of ATP-binding cassette transporter nucleotide-binding domains |
| title_sort | structure and association of atp binding cassette transporter nucleotide binding domains |
| topic | Biochemistry |
| work_keys_str_mv | AT kerri structureandassociationofatpbindingcassettetransporternucleotidebindingdomains |