Persistence of Plasmodium falciparum HRP-2 in successfully treated acute falciparum malaria.
The potential for Plasmodium falciparum histidine-rich protein-2 (PfHRP-2) dipstick tests to predict antimalarial treatment failure was investigated in a prospective study in Thailand of 38 patients admitted with severe malaria and 54 hospitalized with uncomplicated P. falciparum infections. Of thes...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2001
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| _version_ | 1797063398323650560 |
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| author | Mayxay, M Pukrittayakamee, S Chotivanich, K Looareesuwan, S White, N |
| author_facet | Mayxay, M Pukrittayakamee, S Chotivanich, K Looareesuwan, S White, N |
| author_sort | Mayxay, M |
| collection | OXFORD |
| description | The potential for Plasmodium falciparum histidine-rich protein-2 (PfHRP-2) dipstick tests to predict antimalarial treatment failure was investigated in a prospective study in Thailand of 38 patients admitted with severe malaria and 54 hospitalized with uncomplicated P. falciparum infections. Of these, 40 had subsequent recrudescence of their infections. Overall, 89% of patients with severe malaria and 61% of patients with uncomplicated malaria had positive PfHRP-2 dipstick tests for > 2 weeks following the start of treatment. Persistence was correlated positively with admission parasite counts, PfHRP-2 intensity scores and disease severity. PfHRP-2 tests which remained positive for > 2 weeks and PfHRP-2 reactive intensity scores on admission, at day 7 and day 14 did not predict treatment failure independent of admission parasitaemia. Freezing and thawing the blood samples did not significantly affect PfHRP-2 results tested by the dipstick technique. The PfHRP-2 dipstick test provides a useful indicator of recent severe malaria, but does not predict the therapeutic response. |
| first_indexed | 2024-03-06T20:59:16Z |
| format | Journal article |
| id | oxford-uuid:3a53b341-8f0e-4ad6-b1ae-25e718c4177a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:59:16Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:3a53b341-8f0e-4ad6-b1ae-25e718c4177a2022-03-26T14:00:55ZPersistence of Plasmodium falciparum HRP-2 in successfully treated acute falciparum malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3a53b341-8f0e-4ad6-b1ae-25e718c4177aEnglishSymplectic Elements at Oxford2001Mayxay, MPukrittayakamee, SChotivanich, KLooareesuwan, SWhite, NThe potential for Plasmodium falciparum histidine-rich protein-2 (PfHRP-2) dipstick tests to predict antimalarial treatment failure was investigated in a prospective study in Thailand of 38 patients admitted with severe malaria and 54 hospitalized with uncomplicated P. falciparum infections. Of these, 40 had subsequent recrudescence of their infections. Overall, 89% of patients with severe malaria and 61% of patients with uncomplicated malaria had positive PfHRP-2 dipstick tests for > 2 weeks following the start of treatment. Persistence was correlated positively with admission parasite counts, PfHRP-2 intensity scores and disease severity. PfHRP-2 tests which remained positive for > 2 weeks and PfHRP-2 reactive intensity scores on admission, at day 7 and day 14 did not predict treatment failure independent of admission parasitaemia. Freezing and thawing the blood samples did not significantly affect PfHRP-2 results tested by the dipstick technique. The PfHRP-2 dipstick test provides a useful indicator of recent severe malaria, but does not predict the therapeutic response. |
| spellingShingle | Mayxay, M Pukrittayakamee, S Chotivanich, K Looareesuwan, S White, N Persistence of Plasmodium falciparum HRP-2 in successfully treated acute falciparum malaria. |
| title | Persistence of Plasmodium falciparum HRP-2 in successfully treated acute falciparum malaria. |
| title_full | Persistence of Plasmodium falciparum HRP-2 in successfully treated acute falciparum malaria. |
| title_fullStr | Persistence of Plasmodium falciparum HRP-2 in successfully treated acute falciparum malaria. |
| title_full_unstemmed | Persistence of Plasmodium falciparum HRP-2 in successfully treated acute falciparum malaria. |
| title_short | Persistence of Plasmodium falciparum HRP-2 in successfully treated acute falciparum malaria. |
| title_sort | persistence of plasmodium falciparum hrp 2 in successfully treated acute falciparum malaria |
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