Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study.
OBJECTIVE: To investigate the association between alcohol consumption and type 2 diabetes, and determine whether this is modified by sex, body mass index (BMI) and beverage type. DESIGN: Multicentre prospective case-cohort study. SETTING: Eight countries from the European Prospective Investigation i...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2012
|
| _version_ | 1826267769200443392 |
|---|---|
| author | Beulens, J van der Schouw, Y Bergmann, M Rohrmann, S Schulze, M Buijsse, B Grobbee, D Arriola, L Cauchi, S Tormo, M Allen, N van der A, D Balkau, B Boeing, H Clavel-Chapelon, F de Lauzon-Guillan, B Franks, P Froguel, P Gonzales, C Halkjaer, J Huerta, J Kaaks, R Key, T Khaw, K Krogh, V |
| author_facet | Beulens, J van der Schouw, Y Bergmann, M Rohrmann, S Schulze, M Buijsse, B Grobbee, D Arriola, L Cauchi, S Tormo, M Allen, N van der A, D Balkau, B Boeing, H Clavel-Chapelon, F de Lauzon-Guillan, B Franks, P Froguel, P Gonzales, C Halkjaer, J Huerta, J Kaaks, R Key, T Khaw, K Krogh, V |
| author_sort | Beulens, J |
| collection | OXFORD |
| description | OBJECTIVE: To investigate the association between alcohol consumption and type 2 diabetes, and determine whether this is modified by sex, body mass index (BMI) and beverage type. DESIGN: Multicentre prospective case-cohort study. SETTING: Eight countries from the European Prospective Investigation into Cancer and Nutrition cohort. SUBJECTS: A representative baseline sample of 16 154 participants and 12 403 incident cases of type 2 diabetes. INTERVENTIONS: Alcohol consumption assessed using validated dietary questionnaires. MAIN OUTCOME MEASURES: Occurrence of type 2 diabetes based on multiple sources (mainly self-reports), verified against medical information. RESULTS: Amongst men, moderate alcohol consumption was nonsignificantly associated with a lower incidence of diabetes with a hazard ratio (HR) of 0.90 (95% CI: 0.78-1.05) for 6.1-12.0 versus 0.1-6.0 g day(-1) , adjusted for dietary and diabetes risk factors. However, the lowest risk was observed at higher intakes of 24.1-96.0 g day(-1) with an HR of 0.86 (95% CI: 0.75-0.98). Amongst women, moderate alcohol consumption was associated with a lower incidence of diabetes with a hazard ratio of 0.82 (95% CI: 0.72-0.92) for 6.1-12.0 g day(-1) (P interaction gender <0.01). The inverse association between alcohol consumption and diabetes was more pronounced amongst overweight (BMI ≥ 25 kg m(-2) ) than normal-weight men and women (P interaction < 0.05). Adjusting for waist and hip circumference did not alter the results for men, but attenuated the association for women (HR=0.90, 95% CI: 0.79-1.03 for 6.1-12.0 g day(-1) ). Wine consumption for men and fortified wine consumption for women were most strongly associated with a reduced risk of diabetes. CONCLUSIONS: The results of this study show that moderate alcohol consumption is associated with a lower risk of type 2 diabetes amongst women only. However, this risk reduction is in part explained by fat distribution. The relation between alcohol consumption and type 2 diabetes was stronger for overweight than normal-weight women and men. |
| first_indexed | 2024-03-06T20:59:16Z |
| format | Journal article |
| id | oxford-uuid:3a53fd61-7586-4b23-a690-6bcd3cf00c5e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:59:16Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:3a53fd61-7586-4b23-a690-6bcd3cf00c5e2022-03-26T14:00:57ZAlcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3a53fd61-7586-4b23-a690-6bcd3cf00c5eEnglishSymplectic Elements at Oxford2012Beulens, Jvan der Schouw, YBergmann, MRohrmann, SSchulze, MBuijsse, BGrobbee, DArriola, LCauchi, STormo, MAllen, Nvan der A, DBalkau, BBoeing, HClavel-Chapelon, Fde Lauzon-Guillan, BFranks, PFroguel, PGonzales, CHalkjaer, JHuerta, JKaaks, RKey, TKhaw, KKrogh, VOBJECTIVE: To investigate the association between alcohol consumption and type 2 diabetes, and determine whether this is modified by sex, body mass index (BMI) and beverage type. DESIGN: Multicentre prospective case-cohort study. SETTING: Eight countries from the European Prospective Investigation into Cancer and Nutrition cohort. SUBJECTS: A representative baseline sample of 16 154 participants and 12 403 incident cases of type 2 diabetes. INTERVENTIONS: Alcohol consumption assessed using validated dietary questionnaires. MAIN OUTCOME MEASURES: Occurrence of type 2 diabetes based on multiple sources (mainly self-reports), verified against medical information. RESULTS: Amongst men, moderate alcohol consumption was nonsignificantly associated with a lower incidence of diabetes with a hazard ratio (HR) of 0.90 (95% CI: 0.78-1.05) for 6.1-12.0 versus 0.1-6.0 g day(-1) , adjusted for dietary and diabetes risk factors. However, the lowest risk was observed at higher intakes of 24.1-96.0 g day(-1) with an HR of 0.86 (95% CI: 0.75-0.98). Amongst women, moderate alcohol consumption was associated with a lower incidence of diabetes with a hazard ratio of 0.82 (95% CI: 0.72-0.92) for 6.1-12.0 g day(-1) (P interaction gender <0.01). The inverse association between alcohol consumption and diabetes was more pronounced amongst overweight (BMI ≥ 25 kg m(-2) ) than normal-weight men and women (P interaction < 0.05). Adjusting for waist and hip circumference did not alter the results for men, but attenuated the association for women (HR=0.90, 95% CI: 0.79-1.03 for 6.1-12.0 g day(-1) ). Wine consumption for men and fortified wine consumption for women were most strongly associated with a reduced risk of diabetes. CONCLUSIONS: The results of this study show that moderate alcohol consumption is associated with a lower risk of type 2 diabetes amongst women only. However, this risk reduction is in part explained by fat distribution. The relation between alcohol consumption and type 2 diabetes was stronger for overweight than normal-weight women and men. |
| spellingShingle | Beulens, J van der Schouw, Y Bergmann, M Rohrmann, S Schulze, M Buijsse, B Grobbee, D Arriola, L Cauchi, S Tormo, M Allen, N van der A, D Balkau, B Boeing, H Clavel-Chapelon, F de Lauzon-Guillan, B Franks, P Froguel, P Gonzales, C Halkjaer, J Huerta, J Kaaks, R Key, T Khaw, K Krogh, V Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study. |
| title | Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study. |
| title_full | Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study. |
| title_fullStr | Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study. |
| title_full_unstemmed | Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study. |
| title_short | Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study. |
| title_sort | alcohol consumption and risk of type 2 diabetes in european men and women influence of beverage type and body size the epic interact study |
| work_keys_str_mv | AT beulensj alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT vanderschouwy alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT bergmannm alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT rohrmanns alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT schulzem alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT buijsseb alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT grobbeed alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT arriolal alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT cauchis alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT tormom alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT allenn alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT vanderad alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT balkaub alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT boeingh alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT clavelchapelonf alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT delauzonguillanb alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT franksp alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT froguelp alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT gonzalesc alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT halkjaerj alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT huertaj alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT kaaksr alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT keyt alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT khawk alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy AT kroghv alcoholconsumptionandriskoftype2diabetesineuropeanmenandwomeninfluenceofbeveragetypeandbodysizetheepicinteractstudy |