Early-life gut microbiota assembly patterns are conserved between laboratory and wild mice
Assembly of the mammalian gut microbiota during early life is known to shape key aspects of organismal development, including immunity, metabolism and behaviour. While house mice (Mus musculus) are the major laboratory model organism for gut microbiota research, their artificial lab-based lifestyle...
| 主要な著者: | , , |
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| フォーマット: | Journal article |
| 言語: | English |
| 出版事項: |
Nature Research
2024
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| _version_ | 1826315324028354560 |
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| author | Hanski, E Raulo, A Knowles, SCL |
| author_facet | Hanski, E Raulo, A Knowles, SCL |
| author_sort | Hanski, E |
| collection | OXFORD |
| description | Assembly of the mammalian gut microbiota during early life is known to shape key aspects of organismal development, including immunity, metabolism and behaviour. While house mice (Mus musculus) are the major laboratory model organism for gut microbiota research, their artificial lab-based lifestyle could fundamentally alter ecological processes of microbiota assembly and dynamics, in ways that affect their usefulness as a model system. To examine this, here we directly compared patterns of gut microbiota assembly in house mice from the lab and from the wild, making use of a tractable, individually-marked wild population where we could examine patterns of gut microbiota assembly during early life. Despite lab and wild mice harbouring taxonomically distinct communities, we identify striking similarities in multiple patterns of their gut microbiota assembly. Specifically, age-related changes in both alpha and beta diversity, as well as the abundance of predominant phyla and aerotolerance of the microbiota followed parallel trajectories in both settings. These results suggest some degree of intrinsic programme in gut microbiota assembly that transcends variation in taxonomic profiles, and the genetic and environmental background of the host. They further support the notion that despite their artificial environment, lab mice can provide meaningful insights into natural microbiota ecological dynamics in early life and their interplay with host development. |
| first_indexed | 2024-12-09T03:23:39Z |
| format | Journal article |
| id | oxford-uuid:3a63f53c-4e1c-4aa5-aece-826c1a1d4d57 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-12-09T03:23:39Z |
| publishDate | 2024 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | oxford-uuid:3a63f53c-4e1c-4aa5-aece-826c1a1d4d572024-11-21T20:03:31ZEarly-life gut microbiota assembly patterns are conserved between laboratory and wild miceJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3a63f53c-4e1c-4aa5-aece-826c1a1d4d57EnglishJisc Publications RouterNature Research2024Hanski, ERaulo, AKnowles, SCLAssembly of the mammalian gut microbiota during early life is known to shape key aspects of organismal development, including immunity, metabolism and behaviour. While house mice (Mus musculus) are the major laboratory model organism for gut microbiota research, their artificial lab-based lifestyle could fundamentally alter ecological processes of microbiota assembly and dynamics, in ways that affect their usefulness as a model system. To examine this, here we directly compared patterns of gut microbiota assembly in house mice from the lab and from the wild, making use of a tractable, individually-marked wild population where we could examine patterns of gut microbiota assembly during early life. Despite lab and wild mice harbouring taxonomically distinct communities, we identify striking similarities in multiple patterns of their gut microbiota assembly. Specifically, age-related changes in both alpha and beta diversity, as well as the abundance of predominant phyla and aerotolerance of the microbiota followed parallel trajectories in both settings. These results suggest some degree of intrinsic programme in gut microbiota assembly that transcends variation in taxonomic profiles, and the genetic and environmental background of the host. They further support the notion that despite their artificial environment, lab mice can provide meaningful insights into natural microbiota ecological dynamics in early life and their interplay with host development. |
| spellingShingle | Hanski, E Raulo, A Knowles, SCL Early-life gut microbiota assembly patterns are conserved between laboratory and wild mice |
| title | Early-life gut microbiota assembly patterns are conserved between laboratory and wild mice |
| title_full | Early-life gut microbiota assembly patterns are conserved between laboratory and wild mice |
| title_fullStr | Early-life gut microbiota assembly patterns are conserved between laboratory and wild mice |
| title_full_unstemmed | Early-life gut microbiota assembly patterns are conserved between laboratory and wild mice |
| title_short | Early-life gut microbiota assembly patterns are conserved between laboratory and wild mice |
| title_sort | early life gut microbiota assembly patterns are conserved between laboratory and wild mice |
| work_keys_str_mv | AT hanskie earlylifegutmicrobiotaassemblypatternsareconservedbetweenlaboratoryandwildmice AT rauloa earlylifegutmicrobiotaassemblypatternsareconservedbetweenlaboratoryandwildmice AT knowlesscl earlylifegutmicrobiotaassemblypatternsareconservedbetweenlaboratoryandwildmice |