Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG)
Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost 30% of the population in the UK have a family history of CRC. The quantification of an individual's lifetime risk of gastrointestinal cancer may incorporate clinical and molecular data, and depends on ac...
| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , |
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| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
BMJ Journals
2019
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| _version_ | 1826267795383386112 |
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| author | Monahan, KJ Bradshaw, N Dolwani, S Desouza, B Dunlop, MG East, JE Ilyas, M Kaur, A Lalloo, F Latchford, A Rutter, MD Tomlinson, I Thomas, HJW Hill, J Hereditary CRC Guidelines Edelphi Consensus Group |
| author_facet | Monahan, KJ Bradshaw, N Dolwani, S Desouza, B Dunlop, MG East, JE Ilyas, M Kaur, A Lalloo, F Latchford, A Rutter, MD Tomlinson, I Thomas, HJW Hill, J Hereditary CRC Guidelines Edelphi Consensus Group |
| author_sort | Monahan, KJ |
| collection | OXFORD |
| description | Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost 30% of the population in the UK have a family history of CRC. The quantification of an individual's lifetime risk of gastrointestinal cancer may incorporate clinical and molecular data, and depends on accurate phenotypic assessment and genetic diagnosis. In turn this may facilitate targeted risk-reducing interventions, including endoscopic surveillance, preventative surgery and chemoprophylaxis, which provide opportunities for cancer prevention. This guideline is an update from the 2010 British Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland (BSG/ACPGBI) guidelines for colorectal screening and surveillance in moderate and high-risk groups; however, this guideline is concerned specifically with people who have increased lifetime risk of CRC due to hereditary factors, including those with Lynch syndrome, polyposis or a family history of CRC. On this occasion we invited the UK Cancer Genetics Group (UKCGG), a subgroup within the British Society of Genetic Medicine (BSGM), as a partner to BSG and ACPGBI in the multidisciplinary guideline development process. We also invited external review through the Delphi process by members of the public as well as the steering committees of the European Hereditary Tumour Group (EHTG) and the European Society of Gastrointestinal Endoscopy (ESGE). A systematic review of 10 189 publications was undertaken to develop 67 evidence and expert opinion-based recommendations for the management of hereditary CRC risk. Ten research recommendations are also prioritised to inform clinical management of people at hereditary CRC risk. |
| first_indexed | 2024-03-06T20:59:41Z |
| format | Journal article |
| id | oxford-uuid:3a77c9ec-9653-4a55-b4d5-45313a1feef3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:59:41Z |
| publishDate | 2019 |
| publisher | BMJ Journals |
| record_format | dspace |
| spelling | oxford-uuid:3a77c9ec-9653-4a55-b4d5-45313a1feef32022-03-26T14:01:47ZGuidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG)Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3a77c9ec-9653-4a55-b4d5-45313a1feef3EnglishSymplectic Elements at OxfordBMJ Journals2019Monahan, KJBradshaw, NDolwani, SDesouza, BDunlop, MGEast, JEIlyas, MKaur, ALalloo, FLatchford, ARutter, MDTomlinson, IThomas, HJWHill, JHereditary CRC Guidelines Edelphi Consensus GroupHeritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost 30% of the population in the UK have a family history of CRC. The quantification of an individual's lifetime risk of gastrointestinal cancer may incorporate clinical and molecular data, and depends on accurate phenotypic assessment and genetic diagnosis. In turn this may facilitate targeted risk-reducing interventions, including endoscopic surveillance, preventative surgery and chemoprophylaxis, which provide opportunities for cancer prevention. This guideline is an update from the 2010 British Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland (BSG/ACPGBI) guidelines for colorectal screening and surveillance in moderate and high-risk groups; however, this guideline is concerned specifically with people who have increased lifetime risk of CRC due to hereditary factors, including those with Lynch syndrome, polyposis or a family history of CRC. On this occasion we invited the UK Cancer Genetics Group (UKCGG), a subgroup within the British Society of Genetic Medicine (BSGM), as a partner to BSG and ACPGBI in the multidisciplinary guideline development process. We also invited external review through the Delphi process by members of the public as well as the steering committees of the European Hereditary Tumour Group (EHTG) and the European Society of Gastrointestinal Endoscopy (ESGE). A systematic review of 10 189 publications was undertaken to develop 67 evidence and expert opinion-based recommendations for the management of hereditary CRC risk. Ten research recommendations are also prioritised to inform clinical management of people at hereditary CRC risk. |
| spellingShingle | Monahan, KJ Bradshaw, N Dolwani, S Desouza, B Dunlop, MG East, JE Ilyas, M Kaur, A Lalloo, F Latchford, A Rutter, MD Tomlinson, I Thomas, HJW Hill, J Hereditary CRC Guidelines Edelphi Consensus Group Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG) |
| title | Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG) |
| title_full | Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG) |
| title_fullStr | Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG) |
| title_full_unstemmed | Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG) |
| title_short | Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG) |
| title_sort | guidelines for the management of hereditary colorectal cancer from the british society of gastroenterology bsg association of coloproctology of great britain and ireland acpgbi united kingdom cancer genetics group ukcgg |
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