The immunological synapse balances T cell receptor signaling and degradation.

The immunological synapse balances T cell receptor signaling and degradation.

The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in...

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Manylion Llyfryddiaeth
Prif Awduron: Lee, K, Dinner, A, Tu, C, Campi, G, Raychaudhuri, S, Varma, R, Sims, T, Burack, W, Wu, H, Wang, J, Kanagawa, O, Markiewicz, M, Allen, P, Dustin, M, Chakraborty, A, Shaw, A
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 2003
Disgrifiad
Crynodeb:The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.

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