The immunological synapse balances T cell receptor signaling and degradation.

The immunological synapse balances T cell receptor signaling and degradation.

The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in...

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Những tác giả chính: Lee, K, Dinner, A, Tu, C, Campi, G, Raychaudhuri, S, Varma, R, Sims, T, Burack, W, Wu, H, Wang, J, Kanagawa, O, Markiewicz, M, Allen, P, Dustin, M, Chakraborty, A, Shaw, A
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2003
Miêu tả
Tóm tắt:The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.

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