The immunological synapse balances T cell receptor signaling and degradation.
The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2003
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| _version_ | 1826267807643336704 |
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| author | Lee, K Dinner, A Tu, C Campi, G Raychaudhuri, S Varma, R Sims, T Burack, W Wu, H Wang, J Kanagawa, O Markiewicz, M Allen, P Dustin, M Chakraborty, A Shaw, A |
| author_facet | Lee, K Dinner, A Tu, C Campi, G Raychaudhuri, S Varma, R Sims, T Burack, W Wu, H Wang, J Kanagawa, O Markiewicz, M Allen, P Dustin, M Chakraborty, A Shaw, A |
| author_sort | Lee, K |
| collection | OXFORD |
| description | The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals. |
| first_indexed | 2024-03-06T20:59:53Z |
| format | Journal article |
| id | oxford-uuid:3a87eff4-96c6-4d58-845c-1a28c5ac9ffa |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:59:53Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:3a87eff4-96c6-4d58-845c-1a28c5ac9ffa2022-03-26T14:02:08ZThe immunological synapse balances T cell receptor signaling and degradation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3a87eff4-96c6-4d58-845c-1a28c5ac9ffaEnglishSymplectic Elements at Oxford2003Lee, KDinner, ATu, CCampi, GRaychaudhuri, SVarma, RSims, TBurack, WWu, HWang, JKanagawa, OMarkiewicz, MAllen, PDustin, MChakraborty, AShaw, AThe immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals. |
| spellingShingle | Lee, K Dinner, A Tu, C Campi, G Raychaudhuri, S Varma, R Sims, T Burack, W Wu, H Wang, J Kanagawa, O Markiewicz, M Allen, P Dustin, M Chakraborty, A Shaw, A The immunological synapse balances T cell receptor signaling and degradation. |
| title | The immunological synapse balances T cell receptor signaling and degradation. |
| title_full | The immunological synapse balances T cell receptor signaling and degradation. |
| title_fullStr | The immunological synapse balances T cell receptor signaling and degradation. |
| title_full_unstemmed | The immunological synapse balances T cell receptor signaling and degradation. |
| title_short | The immunological synapse balances T cell receptor signaling and degradation. |
| title_sort | immunological synapse balances t cell receptor signaling and degradation |
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