Twisting transition between crystalline and fibrillar phases of aggregated peptides.
We study two distinctly ordered condensed phases of polypeptide molecules, amyloid fibrils and amyloidlike microcrystals, and the first-order twisting phase transition between these two states. We derive a single free-energy form which connects both phases. Our model identifies relevant degrees of f...
Main Authors: | Knowles, T, De Simone, A, Fitzpatrick, A, Baldwin, A, Meehan, S, Rajah, L, Vendruscolo, M, Welland, M, Dobson, C, Terentjev, E |
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Format: | Journal article |
Language: | English |
Published: |
2012
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