Twisting transition between crystalline and fibrillar phases of aggregated peptides.

We study two distinctly ordered condensed phases of polypeptide molecules, amyloid fibrils and amyloidlike microcrystals, and the first-order twisting phase transition between these two states. We derive a single free-energy form which connects both phases. Our model identifies relevant degrees of f...

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Detalhes bibliográficos
Principais autores: Knowles, T, De Simone, A, Fitzpatrick, A, Baldwin, A, Meehan, S, Rajah, L, Vendruscolo, M, Welland, M, Dobson, C, Terentjev, E
Formato: Journal article
Idioma:English
Publicado em: 2012