De novo mutations in DENR disrupt neuronal development and link congenital neurological disorders to faulty mRNA translation re-initiation.

De novo mutations in DENR disrupt neuronal development and link congenital neurological disorders to faulty mRNA translation re-initiation.

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Disruptions to neuronal mRNA translation are hypothesized to underlie human neurodevelopmental syndromes. Notably, the mRNA translation re-initiation factor DENR is a regulator of eukaryotic translation and cell growth, but its mammalian functions are unknown. Here, we report that Denr influences th...

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Bibliographic Details
Main Authors: Haas, M, Ngo, L, Li, S, Schleich, S, Qu, Z, Vanyai, H, Cullen, H, Cardona-Alberich, A, Gladwyn-Ng, I, Pagnamenta, A, Taylor, J, Stewart, H, Kini, U, Duncan, K, Teleman, A, Keays, D, Heng, J
Format: Journal article
Language:English
Published: Elsevier 2016

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