Impact of allogeneic hematopoetic stem cell transplantation on the HIV reservoir and immune response in 3 HIV-infected individuals
<p>Background: Allogeneic hematopoietic stem cell transplantation (HSCT) can lead to significant changes to the HIV reservoir and HIV immune responses, indicating that further characterization of HIV-infected patients undergoing HSCT is warranted.</p><p> Methods: We studied 3 pati...
| Glavni autori: | , , , |
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| Format: | Journal article |
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Lippincott, Williams and Wilkins
2017
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| _version_ | 1826267822502707200 |
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| author | Koelsch, K Rasmussen, T Hey-Nguyen, W Sasson, S |
| author_facet | Koelsch, K Rasmussen, T Hey-Nguyen, W Sasson, S |
| author_sort | Koelsch, K |
| collection | OXFORD |
| description | <p>Background: Allogeneic hematopoietic stem cell transplantation (HSCT) can lead to significant changes to the HIV reservoir and HIV immune responses, indicating that further characterization of HIV-infected patients undergoing HSCT is warranted.</p><p> Methods: We studied 3 patients who underwent HSCT after either reduced intensity conditioning or myeloablative conditioning regimen. We measured HIV antigens and antibodies (Ag/Ab), HIV-specific CD4+ T-cell responses, HIV RNA, and DNA in plasma, peripheral blood mononuclear cells, isolated CD4+ T cells from peripheral blood, and lymph node cells. The patients remained on antiretroviral therapy throughout the follow-up period.</p><p> Results: All patients have been in continued remission for 4–6 years post-HSCT. Analyses of HIV RNA and DNA levels showed substantial reductions in HIV reservoir–related measurements in all 3 patients, changes in immune response varied with pronounced reductions in 2 patients and a less dramatic reduction in 1 patient. One patient experienced unexpected viral rebound 4 years after HSCT.</p><p> Conclusions: These 3 cases highlight the substantial changes to the HIV reservoir and the HIV immune response in patients undergoing allogeneic HSCT. The viral rebound observed in 1 patient indicates that replication competent HIV can re-emerge several years after HSCT despite these marked changes.</p> |
| first_indexed | 2024-03-06T21:00:07Z |
| format | Journal article |
| id | oxford-uuid:3a99f166-b924-4d15-a4e4-5ea6c208b5d0 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T21:00:07Z |
| publishDate | 2017 |
| publisher | Lippincott, Williams and Wilkins |
| record_format | dspace |
| spelling | oxford-uuid:3a99f166-b924-4d15-a4e4-5ea6c208b5d02022-03-26T14:02:33ZImpact of allogeneic hematopoetic stem cell transplantation on the HIV reservoir and immune response in 3 HIV-infected individualsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3a99f166-b924-4d15-a4e4-5ea6c208b5d0Symplectic Elements at OxfordLippincott, Williams and Wilkins2017Koelsch, KRasmussen, THey-Nguyen, WSasson, S<p>Background: Allogeneic hematopoietic stem cell transplantation (HSCT) can lead to significant changes to the HIV reservoir and HIV immune responses, indicating that further characterization of HIV-infected patients undergoing HSCT is warranted.</p><p> Methods: We studied 3 patients who underwent HSCT after either reduced intensity conditioning or myeloablative conditioning regimen. We measured HIV antigens and antibodies (Ag/Ab), HIV-specific CD4+ T-cell responses, HIV RNA, and DNA in plasma, peripheral blood mononuclear cells, isolated CD4+ T cells from peripheral blood, and lymph node cells. The patients remained on antiretroviral therapy throughout the follow-up period.</p><p> Results: All patients have been in continued remission for 4–6 years post-HSCT. Analyses of HIV RNA and DNA levels showed substantial reductions in HIV reservoir–related measurements in all 3 patients, changes in immune response varied with pronounced reductions in 2 patients and a less dramatic reduction in 1 patient. One patient experienced unexpected viral rebound 4 years after HSCT.</p><p> Conclusions: These 3 cases highlight the substantial changes to the HIV reservoir and the HIV immune response in patients undergoing allogeneic HSCT. The viral rebound observed in 1 patient indicates that replication competent HIV can re-emerge several years after HSCT despite these marked changes.</p> |
| spellingShingle | Koelsch, K Rasmussen, T Hey-Nguyen, W Sasson, S Impact of allogeneic hematopoetic stem cell transplantation on the HIV reservoir and immune response in 3 HIV-infected individuals |
| title | Impact of allogeneic hematopoetic stem cell transplantation on the HIV reservoir and immune response in 3 HIV-infected individuals |
| title_full | Impact of allogeneic hematopoetic stem cell transplantation on the HIV reservoir and immune response in 3 HIV-infected individuals |
| title_fullStr | Impact of allogeneic hematopoetic stem cell transplantation on the HIV reservoir and immune response in 3 HIV-infected individuals |
| title_full_unstemmed | Impact of allogeneic hematopoetic stem cell transplantation on the HIV reservoir and immune response in 3 HIV-infected individuals |
| title_short | Impact of allogeneic hematopoetic stem cell transplantation on the HIV reservoir and immune response in 3 HIV-infected individuals |
| title_sort | impact of allogeneic hematopoetic stem cell transplantation on the hiv reservoir and immune response in 3 hiv infected individuals |
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