2-oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2

2-oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2

Prolyl hydroxylation of hypoxia inducible factor (HIF)-α, as catalysed by the Fe(II)/2-oxoglutarate (2OG)-dependent prolyl hydroxylase domain (PHD) enzymes, has a hypoxia sensing role in animals. We report that binding of prolyl-hydroxylated HIF-α to PHD2 is ~50 fold hindered by prior 2OG binding; t...

תיאור מלא

מידע ביבליוגרפי
Main Authors:	Abboud, M, McAllister, T, Leung, I, Chowdhury, R, Jorgensen, C, Domene, C, Mecinović, J, Lippl,, K, Hancock, R, Hopkinson, R, Kawamura, A, Claridge, T, Schofield, C
פורמט:	Journal article
יצא לאור:	Royal Society of Chemistry 2018

פריטים דומים

2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.
מאת: Mecinović, J, et al.
יצא לאור: (2009)

Studies on the substrate selectivity of the hypoxia-inducible factor prolyl hydroxylase 2 catalytic domain
מאת: Abboud, M, et al.
יצא לאור: (2018)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
מאת: Mole, D, et al.
יצא לאור: (2003)

Exploring the substrate selectivity of oxygen sensing prolyl hydroxylases
מאת: Lippl, K, et al.
יצא לאור: (2015)

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.
מאת: McNeill, L, et al.
יצא לאור: (2005)

BIOL 56-ESI-MS studies on prolyl hydroxylase domain 2
מאת: Mecinovic, J, et al.
יצא לאור: (2008)

Use of cyclic peptides to induce crystallization – case study with prolyl hydroxylase domain 2
מאת: Chowdhury, R, et al.
יצא לאור: (2020)

Mass spectrometric studies on an oxygen sensing prolyl hydroxylase
מאת: Mecinovic, J, et al.
יצא לאור: (2007)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
מאת: Chowdhury, R, et al.
יצא לאור: (2016)

Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2.
מאת: Mecinović, J, et al.
יצא לאור: (2009)

Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2
מאת: Rasheduzzaman Chowdhury, et al.
יצא לאור: (2020-12-01)

Inhibition of a viral prolyl hydroxylase
מאת: Langley, G, et al.
יצא לאור: (2019)

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
מאת: Chowdhury, R, et al.
יצא לאור: (2009)

Differential prolyl hydroxylation by six Physcomitrella prolyl-4 hydroxylases
מאת: Christine Rempfer, et al.
יצא לאור: (2024-12-01)

Mechanism of molecular oxygen diffusion in a hypoxia-sensing prolyl hydroxylase using multiscale simulation
מאת: Domene, C, et al.
יצא לאור: (2020)

Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens
מאת: Lippl, K, et al.
יצא לאור: (2018)

2-oxoglutarate-dependent oxygenases
מאת: Islam, M, et al.
יצא לאור: (2018)

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
מאת: Yeh, TL, et al.
יצא לאור: (2017)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
מאת: Cockman, M, et al.
יצא לאור: (2019)

ESI-MS studies on prolyl hydroxylase domain 2 reveal a new metal binding site.
מאת: Mecinović, J, et al.
יצא לאור: (2008)

Monitoring the activity of 2-oxoglutarate dependent histone demethylases by NMR spectroscopy: direct observation of formaldehyde.
מאת: Hopkinson, R, et al.
יצא לאור: (2010)

Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases.
מאת: Loenarz, C, et al.
יצא לאור: (2011)

Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase, and is sensitive to off target inhibition by prolyl hydroxylase domain inhibitors that stabilise Hypoxia Inducible Factor
מאת: Kiriakidis, S, et al.
יצא לאור: (2017)

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
מאת: Holt-Martyn, J, et al.
יצא לאור: (2019)

2-Oxoglutarate oxygenases are inhibited by a range of transition metals.
מאת: Sekirnik, R, et al.
יצא לאור: (2010)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
מאת: Lippl, K
יצא לאור: (2018)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
מאת: Rasheduzzaman Chowdhury, et al.
יצא לאור: (2016-08-01)

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen.
מאת: Tarhonskaya, H, et al.
יצא לאור: (2014)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
מאת: Chan, M, et al.
יצא לאור: (2016)

Structure of proline 3-hydroxylase. Evolution of the family of 2-oxoglutarate dependent oxygenases.
מאת: Clifton, I, et al.
יצא לאור: (2001)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)
מאת: Chowdhury, R, et al.
יצא לאור: (2011)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
מאת: Chowdhury, R, et al.
יצא לאור: (2011)

Human prolyl hydroxylase domain 2 reacts with O 2 and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes
מאת: Fiorini, G, et al.
יצא לאור: (2024)

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
מאת: Hewitson, K, et al.
יצא לאור: (2007)

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.
מאת: Flashman, E, et al.
יצא לאור: (2010)

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.
מאת: Flashman, E, et al.
יצא לאור: (2010)

Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.
מאת: Leung, I, et al.
יצא לאור: (2013)

Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii
מאת: Liu, T, et al.
יצא לאור: (2020)

Human prolyl hydroxylase domain 2 reacts with O2 and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes
מאת: Giorgia Fiorini, et al.
יצא לאור: (2024-10-01)

Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase
מאת: Brewitz, L, et al.
יצא לאור: (2020)