A short history of hemogenic endothelium.
Definitive hematopoietic cells are generated de novo during ontogeny from a specialized subset of endothelium, the so-called hemogenic endothelium. In this review we give a brief overview of the identification of hemogenic endothelium, explore its links with the HSC lineage, and summarize recent ins...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2013
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| _version_ | 1797063492387209216 |
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| author | Swiers, G Rode, C Azzoni, E de Bruijn, M |
| author_facet | Swiers, G Rode, C Azzoni, E de Bruijn, M |
| author_sort | Swiers, G |
| collection | OXFORD |
| description | Definitive hematopoietic cells are generated de novo during ontogeny from a specialized subset of endothelium, the so-called hemogenic endothelium. In this review we give a brief overview of the identification of hemogenic endothelium, explore its links with the HSC lineage, and summarize recent insights into the nature of hemogenic endothelium and the microenvironmental and intrinsic regulators contributing to its transition into blood. Ultimately, a better understanding of the processes controlling the transition of endothelium into blood will advance the generation and expansion of hematopoietic stem cells for therapeutic purposes. |
| first_indexed | 2024-03-06T21:00:39Z |
| format | Journal article |
| id | oxford-uuid:3ac3341d-5333-4abd-8232-b969c998880c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:00:39Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:3ac3341d-5333-4abd-8232-b969c998880c2022-03-26T14:03:33ZA short history of hemogenic endothelium.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3ac3341d-5333-4abd-8232-b969c998880cEnglishSymplectic Elements at Oxford2013Swiers, GRode, CAzzoni, Ede Bruijn, MDefinitive hematopoietic cells are generated de novo during ontogeny from a specialized subset of endothelium, the so-called hemogenic endothelium. In this review we give a brief overview of the identification of hemogenic endothelium, explore its links with the HSC lineage, and summarize recent insights into the nature of hemogenic endothelium and the microenvironmental and intrinsic regulators contributing to its transition into blood. Ultimately, a better understanding of the processes controlling the transition of endothelium into blood will advance the generation and expansion of hematopoietic stem cells for therapeutic purposes. |
| spellingShingle | Swiers, G Rode, C Azzoni, E de Bruijn, M A short history of hemogenic endothelium. |
| title | A short history of hemogenic endothelium. |
| title_full | A short history of hemogenic endothelium. |
| title_fullStr | A short history of hemogenic endothelium. |
| title_full_unstemmed | A short history of hemogenic endothelium. |
| title_short | A short history of hemogenic endothelium. |
| title_sort | short history of hemogenic endothelium |
| work_keys_str_mv | AT swiersg ashorthistoryofhemogenicendothelium AT rodec ashorthistoryofhemogenicendothelium AT azzonie ashorthistoryofhemogenicendothelium AT debruijnm ashorthistoryofhemogenicendothelium AT swiersg shorthistoryofhemogenicendothelium AT rodec shorthistoryofhemogenicendothelium AT azzonie shorthistoryofhemogenicendothelium AT debruijnm shorthistoryofhemogenicendothelium |