Preventing spontaneous genetic rearrangements in the transgene cassettes of adenovirus vectors.
First-generation, E1/E3-deleted adenoviral vectors with diverse transgenes are produced routinely in laboratories worldwide for development of novel prophylactics and therapies for a variety of applications, including candidate vaccines against important infectious diseases, such as HIV/AIDS, tuberc...
Main Authors: | Cottingham, MG, Carroll, F, Morris, S, Turner, A, Vaughan, A, Kapulu, M, Colloca, S, Siani, L, Gilbert, S, Hill, A |
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Format: | Journal article |
Language: | English |
Published: |
2012
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