Genotypic and phenotypic changes during culture of a multinucleoside-resistant human immunodeficiency virus type 1 strain in the presence and absence of additional reverse transcriptase inhibitors.
The observation that human immunodeficiency virus type 1 (HIV-1) mutations conferring resistance to one reverse transcriptase (RT) inhibitor may suppress resistance to other RT inhibitors provides a rationale for treating HIV-1 with certain RT inhibitor combinations. We examined phenotypic and genot...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1996
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| _version_ | 1797063515776745472 |
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| author | Shafer, R Winters, M Iversen, A Merigan, T |
| author_facet | Shafer, R Winters, M Iversen, A Merigan, T |
| author_sort | Shafer, R |
| collection | OXFORD |
| description | The observation that human immunodeficiency virus type 1 (HIV-1) mutations conferring resistance to one reverse transcriptase (RT) inhibitor may suppress resistance to other RT inhibitors provides a rationale for treating HIV-1 with certain RT inhibitor combinations. We examined phenotypic and genotypic changes during culture of a multinucleoside (zidovudine, didanosine, zalcitibine, and stavudine)-resistant HIV-1 strain with and without additional RT inhibitors (nevirapine and lamivudine). The development of nevirapine or lamivudine resistance by the multinucleoside-resistant strain was not accompanied by a reduction in zidovudine or didanosine resistance. |
| first_indexed | 2024-03-06T21:00:59Z |
| format | Journal article |
| id | oxford-uuid:3ade4cfa-6fae-4a97-aa56-45767ddaf676 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:00:59Z |
| publishDate | 1996 |
| record_format | dspace |
| spelling | oxford-uuid:3ade4cfa-6fae-4a97-aa56-45767ddaf6762022-03-26T14:04:11ZGenotypic and phenotypic changes during culture of a multinucleoside-resistant human immunodeficiency virus type 1 strain in the presence and absence of additional reverse transcriptase inhibitors.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3ade4cfa-6fae-4a97-aa56-45767ddaf676EnglishSymplectic Elements at Oxford1996Shafer, RWinters, MIversen, AMerigan, TThe observation that human immunodeficiency virus type 1 (HIV-1) mutations conferring resistance to one reverse transcriptase (RT) inhibitor may suppress resistance to other RT inhibitors provides a rationale for treating HIV-1 with certain RT inhibitor combinations. We examined phenotypic and genotypic changes during culture of a multinucleoside (zidovudine, didanosine, zalcitibine, and stavudine)-resistant HIV-1 strain with and without additional RT inhibitors (nevirapine and lamivudine). The development of nevirapine or lamivudine resistance by the multinucleoside-resistant strain was not accompanied by a reduction in zidovudine or didanosine resistance. |
| spellingShingle | Shafer, R Winters, M Iversen, A Merigan, T Genotypic and phenotypic changes during culture of a multinucleoside-resistant human immunodeficiency virus type 1 strain in the presence and absence of additional reverse transcriptase inhibitors. |
| title | Genotypic and phenotypic changes during culture of a multinucleoside-resistant human immunodeficiency virus type 1 strain in the presence and absence of additional reverse transcriptase inhibitors. |
| title_full | Genotypic and phenotypic changes during culture of a multinucleoside-resistant human immunodeficiency virus type 1 strain in the presence and absence of additional reverse transcriptase inhibitors. |
| title_fullStr | Genotypic and phenotypic changes during culture of a multinucleoside-resistant human immunodeficiency virus type 1 strain in the presence and absence of additional reverse transcriptase inhibitors. |
| title_full_unstemmed | Genotypic and phenotypic changes during culture of a multinucleoside-resistant human immunodeficiency virus type 1 strain in the presence and absence of additional reverse transcriptase inhibitors. |
| title_short | Genotypic and phenotypic changes during culture of a multinucleoside-resistant human immunodeficiency virus type 1 strain in the presence and absence of additional reverse transcriptase inhibitors. |
| title_sort | genotypic and phenotypic changes during culture of a multinucleoside resistant human immunodeficiency virus type 1 strain in the presence and absence of additional reverse transcriptase inhibitors |
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