Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions.

Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions.

Niemann-pick type C1 (NPC1) is an endo/lysosomal membrane protein involved in intracellular cholesterol trafficking, and its luminal domain C is an essential endosomal receptor for Ebola and Marburg viruses. We have determined the crystal structure of glycosylated NPC1 luminal domain C and find all...

Descripció completa

Dades bibliogràfiques
Autors principals:	Zhao, Y, Ren, J, Harlos, K, Stuart, D
Format:	Journal article
Idioma:	English
Publicat:	Wiley 2016

Ítems similars

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins
per: Piyali Saha, et al.
Publicat: (2020-05-01)

The NPC pathway and persistence of intracellular pathogens
per: Weng, Y
Publicat: (2023)

MemoryRepository for AI NPC
per: Shijie Zheng, et al.
Publicat: (2024-01-01)

An overview of the role of Niemann-pick C1 (NPC1) in viral infections and inhibition of viral infections through NPC1 inhibitor
per: Irfan Ahmad, et al.
Publicat: (2023-12-01)

LMP-1 and Nasopharyngeal Carcinoma (NPC)
per: Anggun Indah Budiningrum, et al.
Publicat: (2014-06-01)

Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection
per: Feiran Lu, et al.
Publicat: (2015-12-01)

FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts
per: Newton, J, et al.
Publicat: (2017)

Nasopharyngeal carcinoma (NPC) with liver metastasis in pregnancy
per: Zakaria, Atiqah Farah, et al.
Publicat: (2016)

The role of NPC1L1 in cancer
per: Renshuai Zhang, et al.
Publicat: (2022-08-01)

New Active-Stacked-NPC Multilevel Converter
per: Dan Floricau, et al.
Publicat: (2009-10-01)

The NPC Families Mediate BmNPV Entry
per: Youpeng Fan, et al.
Publicat: (2022-08-01)

The structure of the NPC1L1 N-terminal domain in a closed conformation.
per: Hyock Joo Kwon, et al.
Publicat: (2011-04-01)

Prognostic significance of high NPC2 expression in gastric cancer
per: Yunzhuang Yao, et al.
Publicat: (2023-11-01)

Niemann-Pick Disease Type C (NPDC) by Mutation of <i>NPC1</i> and <i>NPC2</i>: Aberrant Lysosomal Cholesterol Trafficking and Oxidative Stress
per: Dongun Lee, et al.
Publicat: (2023-11-01)

Design and development of neutral-point clamped (NPC) inverter
per: Shan, Yuqing
Publicat: (2020)

Refinements of the Hermite–Hadamard Inequality in NPC Global Spaces
per: Conde Cristian
Publicat: (2018-09-01)

Integrated Control and Modulation for Three-Level NPC Rectifiers
per: Antonio Ventosa-Cutillas, et al.
Publicat: (2019-04-01)

Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid
per: Leslie A McCauliff, et al.
Publicat: (2019-10-01)

Evaluation of the landscape of pharmacodynamic biomarkers in Niemann-Pick Disease Type C (NPC)
per: Sydney Stern, et al.
Publicat: (2024-07-01)

Severe neurometabolic phenotype in npc1−/− zebrafish with a C-terminal mutation
per: Ana Quelle-Regaldie, et al.
Publicat: (2023-03-01)

Toremifene interacts with and destabilizes the Ebola virus glycoprotein
per: Zhao, Y, et al.
Publicat: (2016)

Toremifene interacts with and destabilizes the Ebola virus glycoprotein.
per: Zhao, Y, et al.
Publicat: (2016)

Nonparametric Combination (NPC): A Framework for Testing Elaborate Theories
per: Caughey, Devin, et al.
Publicat: (2018)

Nonparametric combination (NPC): a framework for testing elaborate theories
per: Caughey, D, et al.
Publicat: (2017)

Biomarkers in Nasopharyngeal Carcinoma (NPC): Clinical relevance and prognostic potential
per: Madhan Krishnan, et al.
Publicat: (2024-09-01)

The Role of NK Cells in EBV Infection and EBV-Associated NPC
per: Yi Tian Png, et al.
Publicat: (2021-02-01)

The politics of the NPC meme: Reactionary subcultural practice and vernacular theory
per: Rob Gallagher, et al.
Publicat: (2023-01-01)

Primary treatment results of Nasopharyngeal Carcinoma (NPC) in Yogyakarta, Indonesia.
per: Maarten A Wildeman, et al.
Publicat: (2013-01-01)

Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis.
per: Paula Ortega-Gonzalez, et al.
Publicat: (2022-03-01)

Components of the LINC and NPC complexes coordinately target and translocate a virus into the nucleus to promote infection.
per: Chelsey C Spriggs, et al.
Publicat: (2022-09-01)

Structural and biochemical analysis of the Y-shaped Nup84 subcomplex of the NPC
per: Leksa, Nina Carolina
Publicat: (2012)

NPC photovoltaic grid-connected inverter using proportional-resonant controller
per: Maswood, Ali Iftekhar, et al.
Publicat: (2015)

Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone.
per: Zampieri, S, et al.
Publicat: (2009)

The role of NPC2 gene in glioma was investigated based on bioinformatics analysis
per: Guangwei Zheng, et al.
Publicat: (2024-08-01)

NPC1 links cholesterol trafficking to microglial morphology via the gastrosome
per: Joanna Zareba, et al.
Publicat: (2024-10-01)

Backstepping Control of NPC Multilevel Converter Interfacing AC and DC Microgrids
per: J. Dionísio Barros, et al.
Publicat: (2023-07-01)

A Five Level NPC Inverter Controlled by Using SHEPWM Strategy
per: Noureddine Ould Cherchali, et al.
Publicat: (2011-01-01)

A Study on Neutral-Point Potential in Three-Level NPC Converters
per: Maosong Zhang, et al.
Publicat: (2019-09-01)

Simplified MPC Algorithm of NPC Three-level Inverter Based on SVPWM
per: QIAN Jinyue, et al.
Publicat: (2022-01-01)

The Sterol Transporter Npc2c Controls Intestinal Stem Cell Mitosis and Host–Microbiome Interactions in <i>Drosophila</i>
per: Constantina Neophytou, et al.
Publicat: (2023-10-01)